从头开始制造的小细胞肺癌。
Small cell lung cancers made from scratch.
机构信息
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX.
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
出版信息
J Exp Med. 2019 Mar 4;216(3):476-478. doi: 10.1084/jem.20182216. Epub 2019 Feb 13.
In this issue of , Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.
在本期《科学》杂志中，Chen 等人（https://doi.org/10.1084/jem.20181155）描述了一种将人多能胚胎干细胞（hESCs）转化为与人小细胞肺癌（SCLC）非常相似的肺神经内分泌（NE）肿瘤的新方法。另一项最近的研究使用不同的方法将完全分化的正常人类细胞转化为高级别 NE 肿瘤（Park 等人，2018. https://doi.org/10.1126/science.aat5749）。这些方法及其模型为开发高级别 NE 肿瘤的诊断、预防和治疗方法提供了重要的新资源。
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