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Clin Infect Dis. 2016 Dec 1;63(11):1508-1516. doi: 10.1093/cid/ciw615. Epub 2016 Sep 9.
2
Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.代谢组学定量性状位点（mQTL）图谱绘制表明泛素蛋白酶体系统与心血管疾病发病机制有关。
PLoS Genet. 2015 Nov 5;11(11):e1005553. doi: 10.1371/journal.pgen.1005553. eCollection 2015 Nov.
3
HIV infection and the risk of acute myocardial infarction.HIV 感染与急性心肌梗死风险。
JAMA Intern Med. 2013 Apr 22;173(8):614-22. doi: 10.1001/jamainternmed.2013.3728.
4
Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease.基线代谢组学特征可预测冠心病高危患者的心血管事件。
Am Heart J. 2012 May;163(5):844-850.e1. doi: 10.1016/j.ahj.2012.02.005.
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Metabolic profiles predict adverse events after coronary artery bypass grafting.代谢谱预测冠状动脉旁路移植术后的不良事件。
J Thorac Cardiovasc Surg. 2012 Apr;143(4):873-8. doi: 10.1016/j.jtcvs.2011.09.070. Epub 2012 Feb 4.
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Predicting the risk of cardiovascular disease in HIV-infected patients: the data collection on adverse effects of anti-HIV drugs study.预测HIV感染患者的心血管疾病风险：抗HIV药物不良反应研究的数据收集
Eur J Cardiovasc Prev Rehabil. 2010 Oct;17(5):491-501. doi: 10.1097/HJR.0b013e328336a150.
7
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.外周血代谢谱与冠状动脉疾病及后续心血管事件风险的关联
Circ Cardiovasc Genet. 2010 Apr;3(2):207-14. doi: 10.1161/CIRCGENETICS.109.852814. Epub 2010 Feb 19.
8
Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosis.病毒复制、抗逆转录病毒疗法及免疫缺陷在HIV相关动脉粥样硬化中的作用
AIDS. 2009 Jun 1;23(9):1059-67. doi: 10.1097/QAD.0b013e32832b514b.
9
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease.患有早发性心血管疾病的家族中代谢组学特征的高遗传性。
Mol Syst Biol. 2009;5:258. doi: 10.1038/msb.2009.11. Epub 2009 Apr 7.
10
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.一种与支链氨基酸相关的代谢特征，可区分肥胖和消瘦人群，并导致胰岛素抵抗。
Cell Metab. 2009 Apr;9(4):311-26. doi: 10.1016/j.cmet.2009.02.002.

代谢物可预测 HIV 感染者的心血管疾病事件：一项初步的病例对照研究。

Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.

机构信息

Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 315 Trent Drive, Rm. 178, Durham, NC 27710, USA.

Duke Molecular Physiology Institute, Durham, NC, USA.

出版信息

Metabolomics. 2018 Mar;14(3). doi: 10.1007/s11306-018-1318-z. Epub 2018 Jan 31.

DOI:10.1007/s11306-018-1318-z
PMID:30760970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6370037/
Abstract

INTRODUCTION

Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking.

METHODS

Using tandem flow injection mass spectrometry, we quantified plasma levels of 60 metabolites in 24 matched pairs of PLWH [1:1 with and without known coronary artery disease (CAD)]. Metabolite levels were reduced to interpretable factors using principal components analysis.

RESULTS

Factors derived from short-chain dicarboxylacylcarnitines (SCDA) (p = 0.08) and glutamine/valine (p = 0.003) were elevated in CAD cases compared to controls.

CONCLUSION

SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.

摘要

简介

感染 HIV 的人（PLWH）患心血管疾病（CVD）的风险高于未感染的人。目前缺乏用于定义 CVD 事件风险最高的 PLWH 的风险分层方法。

方法

使用串联流动注射质谱法，我们在 24 对匹配的 PLWH 血浆样本中定量检测了 60 种代谢物（1：1 与已知冠心病（CAD）和无 CAD）。使用主成分分析将代谢物水平简化为可解释的因子。

结果

与对照组相比，CAD 病例中短链二羧酸酰基肉碱（SCDA）（p=0.08）和谷氨酰胺/缬氨酸（p=0.003）衍生的因子升高。

结论

SCDAs 和谷氨酰胺/缬氨酸可能是未来 HIV 感染者心血管风险的有价值的标志物，尚待在更大的队列中验证。