代谢物可预测 HIV 感染者的心血管疾病事件：一项初步的病例对照研究。
Metabolites predict cardiovascular disease events in persons living with HIV: a pilot case-control study.
机构信息
Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, 315 Trent Drive, Rm. 178, Durham, NC 27710, USA.
Duke Molecular Physiology Institute, Durham, NC, USA.
出版信息
Metabolomics. 2018 Mar;14(3). doi: 10.1007/s11306-018-1318-z. Epub 2018 Jan 31.
Abstract
INTRODUCTION
Persons living with HIV (PLWH) are at higher risk for cardiovascular disease (CVD) events than uninfected persons. Current risk-stratification methods to define PLWH at highest risk for CVD events are lacking.
METHODS
Using tandem flow injection mass spectrometry, we quantified plasma levels of 60 metabolites in 24 matched pairs of PLWH [1:1 with and without known coronary artery disease (CAD)]. Metabolite levels were reduced to interpretable factors using principal components analysis.
RESULTS
Factors derived from short-chain dicarboxylacylcarnitines (SCDA) (p = 0.08) and glutamine/valine (p = 0.003) were elevated in CAD cases compared to controls.
CONCLUSION
SCDAs and glutamine/valine may be valuable markers of cardiovascular risk among persons living with HIV in the future, pending validation in larger cohorts.
摘要
简介
感染 HIV 的人（PLWH）患心血管疾病（CVD）的风险高于未感染的人。目前缺乏用于定义 CVD 事件风险最高的 PLWH 的风险分层方法。
方法
使用串联流动注射质谱法，我们在 24 对匹配的 PLWH 血浆样本中定量检测了 60 种代谢物（1：1 与已知冠心病（CAD）和无 CAD）。使用主成分分析将代谢物水平简化为可解释的因子。
结果
与对照组相比，CAD 病例中短链二羧酸酰基肉碱（SCDA）（p=0.08）和谷氨酰胺/缬氨酸（p=0.003）衍生的因子升高。
结论
SCDAs 和谷氨酰胺/缬氨酸可能是未来 HIV 感染者心血管风险的有价值的标志物，尚待在更大的队列中验证。
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