Snowden Ariel W, Buhusi Catalin V
Interdisciplinary Program in Neuroscience, Department of Psychology, Utah State University, Logan, UT, United States.
Front Hum Neurosci. 2019 Jan 29;13:9. doi: 10.3389/fnhum.2019.00009. eCollection 2019.
Previous research has shown that schizophrenia (SZ) patients exhibit impairments in interval timing. The cause of timing impairments in SZ remains unknown but may be explained by a dysfunction in the fronto-striatal circuits. Although the current literature includes extensive behavioral data on timing impairments, there is limited focus on the neural correlates of timing in SZ. The neuroimaging literature included in the current review reports hypoactivation in the dorsal-lateral prefrontal cortex (DLPFC), supplementary motor area (SMA) and the basal ganglia (BG). Timing deficits and deficits in attention and working memory (WM) in SZ are likely due to a dysfunction of dopamine (DA) and gamma-aminobutyric acid (GABA) neurotransmission in the cortico-striatal-thalamo-cortical circuits, which are highly implicated in executive functioning and motor preparation.
先前的研究表明，精神分裂症（SZ）患者在间隔计时方面存在障碍。SZ患者计时障碍的原因尚不清楚，但可能是由额纹状体回路功能障碍所解释。尽管当前文献包含了关于计时障碍的大量行为数据，但对SZ患者计时的神经相关性关注有限。本综述纳入的神经影像学文献报告了背外侧前额叶皮层（DLPFC）、辅助运动区（SMA）和基底神经节（BG）的激活不足。SZ患者的计时缺陷以及注意力和工作记忆（WM）缺陷可能是由于皮质-纹状体-丘脑-皮质回路中多巴胺（DA）和γ-氨基丁酸（GABA）神经传递功能障碍所致，这些回路与执行功能和运动准备密切相关。
