Schmidt School of Medicine, Florida Atlantic University, Boca Raton, Florida.
Department of Pharmacy, University of Napoli Federico II, Naples, Italy.
Phytother Res. 2019 May;33(5):1592-1594. doi: 10.1002/ptr.6315. Epub 2019 Feb 14.
Cannabis (medical marijuana) is generally considered a low toxicity drug. The plant belongs to the family Cannabaceae (Urticales). Two main species may be recognized: Cannabis sativa and Cannabis indica. Plants of this species contain many psychoactive components, the cannabinoids, including the primary psychoactive compound Δ-9-tetrahydrocannabinol (THC), the active substance present in Marijuana. The history of its cultivation and use dates back thousands of years. A possible first documented use for medical purposes of this drug is found in Chinese records dated from 28th century BC. Moreover, the presence of THC has been detected in several internal organs from an Egyptian mummy with a C-dating of approximately 950 BC. Evidence of therapeutic potential for marijuana and its components has been suggested for a large number of medical conditions. Despite this, a variety of cardiovascular complications have been documented. Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-coupled cannabinoid receptors CB and CB has been, in fact, linked to different cardiovascular pathologies. Here, we describe a timely update of possible cardiovascular effects of its use for medical purposes.
大麻（医用大麻）通常被认为是一种低毒性药物。该植物属于大麻科（荨麻目）。可能识别出两种主要的物种：大麻 sativa 和大麻 indica。该种植物含有许多精神活性成分，即大麻素，包括主要的精神活性化合物 Δ-9-四氢大麻酚（THC），这是大麻中存在的活性物质。其种植和使用的历史可以追溯到几千年前。这种药物首次有记载的医用用途可追溯到公元前 28 世纪的中国记录。此外，在一具公元前约 950 年的埃及木乃伊的几个内部器官中检测到了 THC 的存在。大麻及其成分在许多医疗条件下具有治疗潜力的证据已被提出。尽管如此，还是记录了多种心血管并发症。内源性脂质介质内源性大麻素及其 G 蛋白偶联大麻素受体 CB 和 CB 的失调实际上与不同的心血管病理有关。在这里，我们描述了其在医疗用途方面可能产生的心血管影响的最新情况。
