Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA.
J Neuroimaging. 2019 Jul;29(4):454-457. doi: 10.1111/jon.12607. Epub 2019 Feb 13.
We hypothesized that vessel wall MR imaging (VWI) with 3D-time-of-flight magnetic resonance imaging (3D-TOF-MRA) together increases the ability to detect abnormal intracranial vessel segments compared to 3D-TOF-MRA alone.
Ninety-three consecutive subjects with a clinical history of suspected vasculopathy imaged with both VWI and 3D-TOF-MRAs were retrospectively reviewed. The 3D-TOF-MRAs were reviewed by two independent neuroradiologists classifying arterial segments as normal or abnormal based on caliber changes. Following a 2-week wash-out period, the 3D-TOF-MRAs with VWI together were re-evaluated for caliber changes and/or vessel wall enhancement. A third neuroradiologist served as consensus. Significance was assessed by McNemar's test.
Forty-two subjects with VWI and 3D-TOF-MRAs met the inclusion criteria. By 3D-TOF-MRA alone, 12.3% (95% confidence interval [CI], 10.7-15.1) of the arterial segments were identified as abnormal compared to 20.8% (95% CI, 18.2-23.4) by VWI and 3D-TOF-MRA together (P < .0001).
3D-TOF-MRA and VWI together identifies a higher number of abnormal vessel segments than 3D-TOF-MRA alone and may provide a more accurate assessment of disease burden.
我们假设，与单独使用 3D 时间飞跃磁共振血管成像（3D-TOF-MRA）相比，血管壁磁共振成像（VWI）联合 3D-TOF-MRA 可提高检测异常颅内血管节段的能力。
回顾性分析了 93 例有疑似血管病变临床病史的连续患者，他们均接受了 VWI 和 3D-TOF-MRA 检查。两名独立的神经放射科医生使用 3D-TOF-MRA 对动脉节段进行分类，根据管腔变化将其分为正常或异常。在 2 周的洗脱期后，对 VWI 联合 3D-TOF-MRA 的动脉节段进行再评估，以评估管腔变化和/或血管壁增强。第三位神经放射科医生作为共识。通过 McNemar 检验评估统计学意义。
42 例患者同时接受了 VWI 和 3D-TOF-MRA 检查，符合纳入标准。单独使用 3D-TOF-MRA 时，12.3%（95%置信区间[CI]，10.7-15.1）的动脉节段被识别为异常，而 VWI 联合 3D-TOF-MRA 时则有 20.8%（95% CI，18.2-23.4）（P<.0001）。
与单独使用 3D-TOF-MRA 相比，3D-TOF-MRA 和 VWI 联合使用可识别更多的异常血管节段，可能提供更准确的疾病负担评估。
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