Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan.
J Clin Hypertens (Greenwich). 2019 Mar;21(3):421-425. doi: 10.1111/jch.13489. Epub 2019 Feb 13.
Constipation is associated with cardiovascular events. Changes to the intestinal microbiota by constipation can induce atherosclerosis, blood pressure rise, and cardiovascular events. Constipation increases with age and often coexists with cardiovascular risk factors. In addition, strain at stool causes blood pressure rise, which can trigger cardiovascular events such as congestive heart failure, arrhythmia, acute coronary disease, and aortic dissection. However, because cardiovascular medical research often focuses on more dramatic interventions, the risk from constipation can be overlooked. Physicians caring for patients with cardiovascular disease should acknowledge constipation and straining with it as important cardiovascular risk, and prematurely intervene to prevent it. The authors review and discuss the relationship between constipation and cardiovascular disease.
便秘与心血管事件有关。便秘引起的肠道微生物群变化可诱发动脉粥样硬化、血压升高和心血管事件。便秘随年龄增长而增加，常与心血管危险因素并存。此外，排便用力会导致血压升高，从而引发充血性心力衰竭、心律失常、急性冠状动脉疾病和主动脉夹层等心血管事件。然而，由于心血管医学研究通常侧重于更显著的干预措施，因此可能会忽视便秘带来的风险。治疗心血管疾病患者的医生应该认识到便秘和便秘用力是重要的心血管风险，并及早干预以预防它。作者回顾并讨论了便秘与心血管疾病之间的关系。
