Department of Pediatrics, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, Ohio.
University of Cincinnati College of Medicine, Cincinnati, Ohio.
Pediatr Blood Cancer. 2019 Jun;66(6):e27665. doi: 10.1002/pbc.27665. Epub 2019 Feb 14.
Aspirin is the most commonly prescribed antiplatelet agent worldwide, but evidence supporting its use varies by age and disease process. Despite its frequent use in childhood acute ischemic stroke prevention and management, major knowledge gaps exist about optimal pediatric aspirin use, particularly in this setting, where high-quality clinical trials are urgently needed. This review focuses upon the evidence for aspirin use in childhood acute ischemic stroke, includes a summary of aspirin pharmacology to highlight misconceptions and common clinical situations which may limit its efficacy, and discusses the techniques and potential role of laboratory monitoring of aspirin efficacy in children.
阿司匹林是全球最常用的抗血小板药物，但支持其使用的证据因年龄和疾病过程而异。尽管阿司匹林在儿童急性缺血性脑卒中的预防和治疗中经常使用，但关于最佳儿科阿司匹林使用的知识仍存在很大的差距，特别是在这种情况下，迫切需要高质量的临床试验。本综述重点介绍了阿司匹林在儿童急性缺血性脑卒中中的应用证据，总结了阿司匹林的药理学知识，以突出可能限制其疗效的误解和常见临床情况，并讨论了儿童阿司匹林疗效的实验室监测技术和潜在作用。
