Dai Peng-Fei, Qu Jian-Ping, Kang Yan-Biao
Department of Chemistry , University of Science and Technology of China , Hefei , Anhui 230026 , China.
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials , Nanjing Tech University , Nanjing 211816 , China.
Org Lett. 2019 Mar 1;21(5):1393-1396. doi: 10.1021/acs.orglett.9b00101. Epub 2019 Feb 14.
The first example organocatalyzed aerobic oxidation of aldehydes to carboxylic acids in both organic solvent and water under mild conditions is developed. As low as 5 mol % N-hydroxyphthalimide was used as the organocatalyst, and molecular O was used as the sole oxidant. No transition metals or hazardous oxidants or cocatalysts were involved. A wide range of carboxylic acids bearing diverse functional groups were obtained from aldehydes, even from alcohols, in high yields.
首次开发了在温和条件下在有机溶剂和水中将醛有机催化有氧氧化为羧酸的方法。仅使用低至5 mol%的N-羟基邻苯二甲酰亚胺作为有机催化剂，分子氧作为唯一的氧化剂。该反应不涉及过渡金属、危险氧化剂或助催化剂。从醛甚至醇中可以高产率地获得多种带有不同官能团的羧酸。
