肿瘤坏死因子-肿瘤坏死因子受体2信号传导抑制Th2和Th17极化并减轻过敏性气道炎症。
TNF-TNFR2 Signaling Inhibits Th2 and Th17 Polarization and Alleviates Allergic Airway Inflammation.
作者信息
Peng Juan, Li Xiao-Ming, Zhang Guo-Rui, Cheng Yi, Chen Xi, Gu Wen, Guo Xue-Jun
机构信息
Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China,
Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Int Arch Allergy Immunol. 2019;178(3):281-290. doi: 10.1159/000493583. Epub 2019 Feb 14.
BACKGROUND
TNF-TNFR2 signaling has been indicated to be involved in CD4+ T lymphocyte differentiation. However, its role in allergic airway inflammation is not well understood.
OBJECTIVES
The aim of this study was to investigate the role of TNF-TNFR2 signaling in allergic airway inflammation.
METHODS AND RESULTS
In this study, we used an allergen-induced asthma model to show that TNF-TNFR2 signaling alleviated allergic airway inflammation by reducing the airway infiltration of eosinophils and neutrophils. Activated TNF-TNFR2 signaling decreased the expression of Th2 and Th17 cytokines in serum and bronchoalveolar lavage fluid. Furthermore, TNF-TNFR2 signaling inhibited Th2 and Th17 polarization but promoted Th1 and CD4+CD25+ T cell differentiation in vivo.
CONCLUSIONS
Our study indicates that TNF-TNFR2 signaling alleviates allergic airway inflammation through inhibition of Th2 and Th17 cell differentiation.
背景
肿瘤坏死因子（TNF）-肿瘤坏死因子受体2（TNFR2）信号通路已被证实参与CD4 + T淋巴细胞分化。然而，其在过敏性气道炎症中的作用尚未完全明确。
目的
本研究旨在探讨TNF-TNFR2信号通路在过敏性气道炎症中的作用。
方法与结果
在本研究中，我们使用变应原诱导的哮喘模型，结果表明TNF-TNFR2信号通路通过减少嗜酸性粒细胞和中性粒细胞的气道浸润来减轻过敏性气道炎症。激活的TNF-TNFR2信号通路可降低血清和支气管肺泡灌洗液中Th2和Th17细胞因子的表达。此外，TNF-TNFR2信号通路在体内抑制Th2和Th17极化，但促进Th1和CD4 + CD25 + T细胞分化。
结论
我们的研究表明，TNF-TNFR2信号通路通过抑制Th2和Th17细胞分化来减轻过敏性气道炎症。
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