Gilding L Niall, Somervaille Tim C P
Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4JG, UK.
Cancers (Basel). 2019 Feb 5;11(2):184. doi: 10.3390/cancers11020184.
Forkhead box C1 (FOXC1) is a transcription factor with essential roles in mesenchymal lineage specification and organ development during normal embryogenesis. In keeping with these developmental properties, mutations that impair the activity of FOXC1 result in the heritable Axenfeld-Rieger Syndrome and other congenital disorders. Crucially, gain of FOXC1 function is emerging as a recurrent feature of malignancy; FOXC1 overexpression is now documented in more than 16 cancer types, often in association with an unfavorable prognosis. This review explores current evidence for FOXC1 deregulation in cancer and the putative mechanisms by which FOXC1 confers its oncogenic effects.
叉头框C1（FOXC1）是一种转录因子，在正常胚胎发育过程中的间充质谱系特化和器官发育中发挥着重要作用。与这些发育特性一致，损害FOXC1活性的突变会导致遗传性Axenfeld-Rieger综合征和其他先天性疾病。至关重要的是，FOXC1功能的获得正成为恶性肿瘤的一个反复出现的特征；目前已有超过16种癌症类型记录到FOXC1过表达，且通常与不良预后相关。本综述探讨了目前关于癌症中FOXC1失调的证据以及FOXC1发挥致癌作用的假定机制。
