Saria A
Department of Psychiatry, University of Innsbruck Medical School, Austria.
Brain Behav Immun. 1988 Dec;2(4):318-21. doi: 10.1016/0889-1591(88)90034-7.
Recent evidence suggests that several bioactive polypeptides, among them substance P, neurokinin A, and calcitonin gene-related peptide, are contained in tracheobronchial C-fibers. These peptides can be released from the lung by irritant chemicals or local inflammatory mediators like histamine or bradykinin. Substance P mimics the increase in vascular permeability caused by vagal nerve stimulation and neurokinin A mimics noncholinergic bronchoconstriction by vagal nerve stimulation. Calcitonin gene-related peptide displays vasodilator activity. Experiments carried out with sensitized guinea pigs showed a contribution of tracheobronchial C-fibers to the anaphylactic response. Additionally, capsaicin, which in high concentration selectively blocks sensory C-fibers, was found to be effective in treatment of hyperreactive rhinopathy (vasomotor rhinitis). It is concluded that peptide mediators released from tracheobronchial C-fibers may contribute to the pathophysiology of various allergic or inflammatory airway diseases.
最近的证据表明，气管支气管C纤维中含有几种生物活性多肽，其中包括P物质、神经激肽A和降钙素基因相关肽。这些肽可通过刺激性化学物质或组胺、缓激肽等局部炎症介质从肺中释放出来。P物质可模拟迷走神经刺激引起的血管通透性增加，神经激肽A可模拟迷走神经刺激引起的非胆碱能支气管收缩。降钙素基因相关肽具有血管舒张活性。对致敏豚鼠进行的实验表明，气管支气管C纤维对过敏反应有作用。此外，高浓度的辣椒素可选择性阻断感觉C纤维，已发现其对治疗高反应性鼻病（血管运动性鼻炎）有效。得出的结论是，气管支气管C纤维释放的肽介质可能在各种过敏性或炎症性气道疾病的病理生理学中起作用。
