Hoffman Madelein, Ipp Hayley, Phatlhane Dineo V, Erasmus Rajiv T, Zemlin Annalise E
Division of Chemical Pathology, National Health Laboratory Service (NHLS) and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.
Division of Haematology, National Health Laboratory Service (NHLS) and Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa.
Afr Health Sci. 2018 Dec;18(4):1066-1075. doi: 10.4314/ahs.v18i4.28.
E-selectin has been shown to play a role in atherosclerosis and to be increased in HIV-infected individuals due to chronic immune activation. There is a paucity of studies on E-selectin in HIV-infected treatment-naïve individuals.
This study aimed to determine whether E-selectin levels were increased in HIV-infected treatment-naïve individuals and whether these correlated with markers of disease severity, inflammation and coagulation to determine if this population is at risk for cardiovascular disease (CVD).
E-selectin levels were determined in 114 HIV-infected treatment-naive and 66 HIV-negative individuals, compared between groups and correlated with markers of disease severity, inflammation and coagulation.
There were statistically significant differences (p<0.01) in levels of WCC, CD4 count, %CD38/8, albumin, IgG, hsCRP and D-dimer between groups and no statistically significant differences in E-selectin (p=0.84) and fibrinogen (p=0.65) levels. E-selectin correlated with age (p=0.02) and gender (p=0.01).
E-selectin was a poor marker in this setting. There was no correlation with any of the markers of disease severity, inflammation and coagulation. E-selectin is most likely raised in an acute inflammatory setting, rather than chronic stage of HIV-infection. We recommend that other markers be utilized to identify patients at increased risk of CVD; as these were significantly increased untreated in individuals.
E选择素已被证明在动脉粥样硬化中起作用，并且由于慢性免疫激活，在HIV感染者中水平会升高。关于未接受过治疗的HIV感染者中E选择素的研究较少。
本研究旨在确定未接受过治疗的HIV感染者中E选择素水平是否升高，以及这些水平是否与疾病严重程度、炎症和凝血标志物相关，以确定该人群是否有心血管疾病（CVD）风险。
测定了114例未接受过治疗的HIV感染者和66例HIV阴性个体的E选择素水平，比较了两组之间的差异，并将其与疾病严重程度、炎症和凝血标志物相关联。
两组之间白细胞计数、CD4细胞计数、%CD38/8、白蛋白、免疫球蛋白G、高敏C反应蛋白和D-二聚体水平存在统计学显著差异（p<0.01），而E选择素（p=0.84）和纤维蛋白原（p=0.65）水平无统计学显著差异。E选择素与年龄（p=0.02）和性别（p=0.01）相关。
在这种情况下，E选择素是一个较差的标志物。它与疾病严重程度、炎症和凝血的任何标志物均无相关性。E选择素很可能在急性炎症情况下升高，而非在HIV感染的慢性阶段。我们建议使用其他标志物来识别CVD风险增加的患者；因为在未治疗的个体中这些标志物显著升高。
