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腹腔镜阑尾切除术后腹腔内脓肿形成的危险因素——来自Pol-LA(波兰腹腔镜阑尾切除术)多中心大型队列研究的结果

Risk factors for intraabdominal abscess formation after laparoscopic appendectomy - results from the Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study.

作者信息

Lasek Anna, Pędziwiatr Michał, Wysocki Michał, Mavrikis Judene, Myśliwiec Piotr, Stefura Tomasz, Bobowicz Maciej, Major Piotr, Rubinkiewicz Mateusz

机构信息

2 Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland.

Centre for Research, Training and Innovation in Surgery (CERTAIN Surgery), Krakow, Poland.

出版信息

Wideochir Inne Tech Maloinwazyjne. 2019 Jan;14(1):70-78. doi: 10.5114/wiitm.2018.77272. Epub 2018 Jul 24.

Abstract

INTRODUCTION

According to meta-analyses laparoscopic appendectomy is associated with many benefits. However, in comparison to open surgery an increased rate of intraabdominal abscesses (IAA) has been reported. Identification of predictive factors for this complication may help to identify patients with higher risk of IAA.

AIM

To identify potential risk factors for intraabdominal abscess after laparoscopic appendectomy (LA).

MATERIAL AND METHODS

Eighteen surgical units in Poland and Germany submitted data of patients undergoing LA to the online web-based database created by the Polish Videosurgery Society of the Association of Polish Surgeons. It comprised 31 elements related to the pre-, intra- and postoperative period. Surgical outcomes were compared among the groups according to occurrence of IAA. Univariate and multivariate logistic regression models were used to identify potential risk factors for IAA.

RESULTS

4618 patients were included in the analysis. IAA were found in 51 (1.10%) cases. Although several risk factors were found in univariate analysis, in the multivariate model, only the presence of complicated appendicitis was statistically significant (OR = 2.98, 95% CI: 1.11-8.04). Moreover, IAA has a significant influence on postoperative reintervention rate (OR = 126.95, 95% CI: 67.98-237.06), prolonged length of stay > 8 days (OR = 41.32, 95% CI: 22.86-74.72) and readmission rate (OR = 33.89, 95% CI: 18.60-34.73).

CONCLUSIONS

Intraabdominal abscesses occurs relatively rarely after LA. It is strongly associated with complicated appendicitis. Occurrence of this complication has a great influence on the postoperative period and due to the nature of its treatment is associated with the need for reintervention, prolonged length of stay and by extension possible readmission.

摘要

引言

根据荟萃分析,腹腔镜阑尾切除术有诸多益处。然而,与开放手术相比,腹腔内脓肿(IAA)的发生率有所增加。识别该并发症的预测因素可能有助于确定IAA风险较高的患者。

目的

确定腹腔镜阑尾切除术(LA)后腹腔内脓肿的潜在风险因素。

材料与方法

波兰和德国的18个外科单位将接受LA治疗的患者数据提交至波兰外科医生协会波兰视频外科学会创建的在线网络数据库。该数据库包含31个与术前、术中和术后阶段相关的要素。根据IAA的发生情况对各组的手术结果进行比较。采用单因素和多因素逻辑回归模型确定IAA的潜在风险因素。

结果

4618例患者纳入分析。51例(1.10%)发现有IAA。虽然在单因素分析中发现了几个风险因素,但在多因素模型中,只有复杂性阑尾炎具有统计学意义(OR = 2.98,95% CI:1.11 - 8.04)。此外,IAA对术后再次干预率(OR = 126.95,95% CI:67.98 - 237.06)、住院时间延长> 8天(OR = 41.32,95% CI:22.86 - 74.72)和再入院率(OR = 33.89,95% CI:18.60 - 34.73)有显著影响。

结论

LA后腹腔内脓肿相对少见。它与复杂性阑尾炎密切相关。该并发症的发生对术后恢复有很大影响,且因其治疗性质与再次干预的必要性、住院时间延长以及可能的再入院相关。

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