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复杂性阑尾炎——腹腔镜手术方法是否合适?与开放手术方法的比较研究:社区医院环境下的结果

Complicated appendicitis--is the laparoscopic approach appropriate? A comparative study with the open approach: outcome in a community hospital setting.

作者信息

Pokala Naveen, Sadhasivam S, Kiran R P, Parithivel V

机构信息

Bronx-Lebanon Hospital Center, Bronx, New York, USA.

出版信息

Am Surg. 2007 Aug;73(8):737-41; discussion 741-2.

Abstract

Good outcome has been reported with the laparoscopic approach in uncomplicated appendicitis, but a higher incidence of postoperative intraabdominal abscesses has been reported after laparoscopic appendectomy in complicated appendicitis. This retrospective comparative study compares outcome after laparoscopic (LA) and open appendectomy (OA) in complicated appendicitis. All patients who had LA or OA for complicated appendicitis between January 2003 and February 2006 were included in the study. Data collection included demographics, operative time, estimated blood loss, length of stay (LOS), complications, readmission, and reoperative rates. The primary end points for analysis were postoperative intraabdominal abscess and complication rates and secondary end points were LOS and operative time. All data were analyzed on an intent-to-treat basis. Of 104 patients, 43 patients underwent LA and 61 had OA. The mean age (24.8 +/- 16.5 versus 31.3 +/- 18.9, P = 0.08) in the LA group was lower than the OA group because there was a significantly higher proportion of pediatric patients (34.8% versus 14.8%, P = 0.02) who had LA. There was no significant difference in gender (female/male, 14/29 versus 27/34, P = 0.3) or American Society of Anesthesiologists class distribution (American Society of Anesthesiologists 1/2/3/4/, 35/7/1/0 versus 45/12/3/1, P = 0.68) between the two groups. The operative time (100.5 +/- 36.2 versus 81.5 +/- 29.5 minutes, P = 0.03) was significantly longer and the estimated blood loss (21 mL versus 33 mL, P = 0.01) was lower in LA when compared with OA, but there was no significant difference in the number of patients with preoperative peritonitis versus abscesses (7/36 versus 13/48, P = 0.6) in both groups. There was no difference in the median LOS (6 [interquartile range 5-9] versus 6 [interquartile range 4-8], P = 0.7) in the two groups. The conversion rate in LA was 18.6% (n = 8). There was also no significant difference in the complication (17/43 [39.5%] versus 21/61 [34.4%], P = 0.54), reoperative (3/43 [7%] versus 0/61 [0%], P = 0.07), and 30-day readmission (5/41 [11.6%] versus 3/61 [4.9%], P = 0.23) rates between the two groups. The rate of postoperative intraabdominal abscesses was significantly higher in the LA group when compared with the OA group (6/43 [14%] versus 0/61 [0%], P = 0.04) and the wound infection (1/43 [2.3%] versus 5/61 [8.2%], P = 0.4) and pulmonary complication (0/43 [0%] versus 3/61 [4.9%], P = 0.26) rate was higher in the OA group. There was no mortality in the LA group, but there was one mortality in the OA group resulting from postoperative myocardial infarction. Laparoscopic appendectomy can be performed in patients with complicated appendicitis with a comparative operative time, LOS, and complication rates but results in a significantly higher intraabdominal abscess rate and lower wound infection rate when compared with OA.

摘要

对于非复杂性阑尾炎,腹腔镜手术方法已报告有良好的治疗效果,但对于复杂性阑尾炎,腹腔镜阑尾切除术后腹腔内脓肿的发生率较高。这项回顾性对照研究比较了复杂性阑尾炎患者接受腹腔镜阑尾切除术(LA)和开腹阑尾切除术(OA)后的治疗效果。2003年1月至2006年2月间因复杂性阑尾炎接受LA或OA手术的所有患者均纳入本研究。数据收集包括人口统计学资料、手术时间、估计失血量、住院时间(LOS)、并发症、再次入院率和再次手术率。分析的主要终点是术后腹腔内脓肿和并发症发生率,次要终点是LOS和手术时间。所有数据均按意向性治疗原则进行分析。104例患者中,43例行LA,61例行OA。LA组的平均年龄(24.8±16.5岁对31.3±18.9岁,P = 0.08)低于OA组,因为LA组儿科患者比例显著更高(34.8%对14.8%,P = 0.02)。两组间性别(女性/男性,14/29对27/34,P = 0.3)或美国麻醉医师协会分级分布(美国麻醉医师协会1/2/3/4级,35/7/1/0对45/12/3/1,P = 0.68)无显著差异。与OA相比,LA的手术时间(100.5±36.2分钟对81.5±29.5分钟,P = 0.03)显著更长,估计失血量(21 mL对33 mL,P = 0.01)更低,但两组术前腹膜炎与脓肿患者数量无显著差异(7/36对13/48,P = 0.6)。两组的中位LOS无差异(6[四分位间距5 - 9]对6[四分位间距4 - 8],P = 0.7)。LA的中转率为18.6%(n = 8)。两组间并发症发生率(17/43[39.5%]对21/61[34.4%],P = 0.54)、再次手术率(3/43[7%]对0/61[0%],P = 0.07)和30天再入院率(5/41[11.6%]对3/61[4.9%],P = 0.23)也无显著差异。与OA组相比,LA组术后腹腔内脓肿发生率显著更高(6/43[14%]对0/61[0%],P = 0.04),OA组伤口感染率(1/43[2.3%]对5/61[8.2%],P = 0.4)和肺部并发症发生率(0/43[0%]对3/61[4.9%],P = 0.26)更高。LA组无死亡病例,但OA组有1例因术后心肌梗死死亡。复杂性阑尾炎患者可进行腹腔镜阑尾切除术,其手术时间、LOS和并发症发生率具有可比性,但与OA相比,腹腔内脓肿发生率显著更高,伤口感染率更低。

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