Hart W L, Parmley L F
J Clin Psychiatry. 1978 Oct;39(10 Pt 2):41-5.
Sixty-two adults with a current diagnosis of significant hypertension and accompanying moderate to severe anxiety were medicated with lorazepam or with placebo for a period of 4 weeks. The patients were assessed by 7 cardiologists under double-blind conditions and the results pooled. Symptoms of anxiety were quantified using a Global Physician Rating, the Hamilton Anxiety Scale and a Patient Self-Rating Scale. The symptoms of anxiety associated with hypertension were significantly relieved by lorazepam in comparison to placebo. Most lorazepam patients were controlled with 3 mg/day; except for 1 patient, side effects were mild and transient.
62名目前被诊断患有严重高血压并伴有中度至重度焦虑的成年人接受了为期4周的劳拉西泮或安慰剂治疗。在双盲条件下，由7位心脏病专家对患者进行评估，并汇总结果。使用全球医生评定量表、汉密尔顿焦虑量表和患者自评量表对焦虑症状进行量化。与安慰剂相比，劳拉西泮能显著缓解与高血压相关的焦虑症状。大多数服用劳拉西泮的患者每天服用3毫克即可得到控制；除1名患者外，副作用轻微且短暂。
