Finkel S
J Clin Psychiatry. 1978 Oct;39(10 Pt 2):35-40.
Lorazepam was administered to 38 patients with moderate to severe anxiety associated with cardiovascular symptomatology. A comparable group of patients on placebo (35) served as controls in this 4-week study. Average dosage was 3 mg/day given as 2 mg in the evening and 1 mg in the morning. The Global response, Hamilton Anxiety Rating Scale scores, and 35-Item Self-Rating Scale scores showed lorazepam to be significantly more effective in relieving anxiety than placebo, both clinically and statistically. Adverse reactions were transient and tolerable, and were reported in only 2 patients on lorazepam.
对38例伴有心血管症状的中重度焦虑患者给予劳拉西泮治疗。在这项为期4周的研究中，一组服用安慰剂的可比患者（35例）作为对照。平均剂量为每日3毫克，晚上服用2毫克，早上服用1毫克。总体反应、汉密尔顿焦虑量表评分和35项自评量表评分显示，劳拉西泮在缓解焦虑方面在临床和统计学上均显著优于安慰剂。不良反应短暂且可耐受，仅2例服用劳拉西泮的患者报告有不良反应。
