Rolfe M
Nkana Division, Zambia Consolidated Copper Mines, Kitwe.
Trans R Soc Trop Med Hyg. 1988;82(4):554-7. doi: 10.1016/0035-9203(88)90502-0.
A 24 year old Zambian female presented with falciparum malaria when 27 weeks pregnant. She had recently travelled to the copperbelt from Solwezi in the North-West Province of Zambia. Oral chloroquine in a dose of 29 mg/kg failed to clear the parasitaemia. Chloroquine resistance was confirmed by testing in vitro and in vivo. In addition, Fansidar (2 courses), amodiaquine, quinine and quinine plus erythromycin failed to achieve radical cure. Quinine resistance was confirmed in vitro and in vivo. She was eventually cured by 10 d of quinine plus clindamycin, which was greatly assisted by the spontaneous delivery of a live normal infant at 37 weeks gestation. The baby's birth weight was 2.68 kg and its blood slide was negative for malaria.
一名24岁的赞比亚女性在怀孕27周时患上恶性疟疾。她最近从赞比亚西北省的索卢韦齐前往铜带省。口服29毫克/千克剂量的氯喹未能清除寄生虫血症。通过体外和体内测试证实了对氯喹的耐药性。此外， Fansidar（2个疗程）、阿莫地喹、奎宁以及奎宁加红霉素均未能实现根治。体外和体内测试均证实了对奎宁的耐药性。她最终通过10天的奎宁加克林霉素治疗得以治愈，37周妊娠时自然分娩出一名健康的正常婴儿对治疗有很大帮助。婴儿出生体重为2.68千克，其血涂片疟原虫检测呈阴性。
