Mancianti F, Gramiccia M, Gradoni L, Pieri S
Dipartimento di Patologia Animale, Università di Pisa, Italy.
Trans R Soc Trop Med Hyg. 1988;82(4):566-7. doi: 10.1016/0035-9203(88)90510-x.
81 dogs naturally infected with Leishmania infantum in the Isle of Elba, Italy, were treated with meglumine antimoniate (Glucantime). 36 of them (45.5%) were asymptomatic cases. 4-24 months after treatment the dogs were clinically and serologically examined; the recovery rates were 47.2% for asymptomatic cases, 33.3% for oligosymptomatic cases, and 11.1% for symptomatic cases. Furthermore, treatment had prevented the development of patent disease in 90% of non-recovered asymptomatic cases, whereas it had produced only slight improvement of clinical condition in patent dogs which were still infected after drug administration. Treatment with antimonial drugs is therefore recommended in canine leishmaniasis control if non-patent or sub-clinical forms of the disease are detected by seroepidemiological surveys.
在意大利厄尔巴岛，对81只自然感染婴儿利什曼原虫的犬使用葡甲胺锑酸盐（葡糖酸锑钠）进行治疗。其中36只（45.5%）为无症状病例。治疗后4至24个月，对这些犬进行临床和血清学检查；无症状病例的恢复率为47.2%，轻度症状病例为33.3%，有症状病例为11.1%。此外，治疗预防了90%未恢复的无症状病例出现显性疾病，而对于用药后仍受感染的显性犬，治疗仅使临床状况稍有改善。因此，如果通过血清流行病学调查发现疾病的非显性或亚临床形式，在犬利什曼病防控中推荐使用锑剂治疗。
