埃及肥胖受试者中脂肪量和肥胖相关基因（）和瘦素受体基因（）多态性。
Fat mass and obesity-associated () and leptin receptor () gene polymorphisms in Egyptian obese subjects.
机构信息
Department of Chemistry, Biochemistry Section, Faculty of Science, Tanta University, Tanta, Egypt.
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
Arch Physiol Biochem. 2021 Feb;127(1):28-36. doi: 10.1080/13813455.2019.1573841. Epub 2019 Feb 15.
BACKGROUND
Several studies addressed the contribution of fat mass and obesity-associated () and leptin receptor () polymorphisms for the susceptibility to obesity among different ethnic subjects. The main purpose of this work is to evaluate the association of these polymorph\isms with obesity among Egyptian subjects.
SUBJECTS AND METHODS
This case-control study was carried out on 110 unrelated obese Egyptian subjects who were compared with 122 controls. Their genomic DNA was genotyped using the PCR technique.
RESULTS
The allelic frequencies of (A) and (223R) were significantly higher in obese subjects compared with non-obese controls ( < .001). Comparing different phenotype frequencies including clinical, anthropometric, and biochemical parameters in obese subjects revealed no significant difference in relation to their genotype frequencies (> .05).
CONCLUSIONS
This study designates a strong association for and variants with the risk of obesity among Egyptian subjects.
背景
多项研究探讨了脂肪量和肥胖相关（）和瘦素受体（）多态性对不同种族人群肥胖易感性的影响。这项工作的主要目的是评估这些多态性与埃及人群肥胖的关系。
受试者和方法
这项病例对照研究共纳入 110 例无相关性的肥胖埃及受试者，并与 122 例对照进行比较。采用聚合酶链反应技术对他们的基因组 DNA 进行基因分型。
结果
与非肥胖对照组相比，肥胖受试者的（A）和（223R）等位基因频率明显更高（<0.001）。在肥胖受试者中比较不同表型频率，包括临床、人体测量和生化参数，与他们的基因型频率无显著差异（>0.05）。
结论
本研究设计表明，在埃及人群中，和变体与肥胖的风险有很强的关联。
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