Department of Anesthesiology.
Department of Anesthesiology, University of Washington.
J Neurosurg Anesthesiol. 2019 Jan;31(1):163-165. doi: 10.1097/ANA.0000000000000542.
The potential for long-term neurotoxic effects of anesthetics on the developing human brain has led to intensified research in this area. To date, the human evidence has been inconclusive, but a large body of animal evidence continues to demonstrate cause for concern. On April 14 and 15, 2018 the sixth biennial Pediatric Anesthesia and Neurodevelopmental Assessment (PANDA) study symposium was held at Morgan Stanley Children's Hospital of New York. This symposium brought together clinicians and researchers and served as a platform to review preclinical and clinical data related to anesthesia and neurotoxicity in developing brains. The program participants included many active investigators in the field of anesthesia neurotoxicity as well as stakeholders from different backgrounds with the common interest of potential anesthetic neurotoxicity in children. The moderated poster session included presentations of preclinical animal research studies. These studies focused on defining the anesthetic-induced neurotoxicity phenotype, understanding the mechanism of injury and discovering potential inhibitors of neurotoxic effects.
麻醉药物对发育中人类大脑的长期神经毒性作用的可能性促使该领域的研究不断深入。迄今为止，人类的证据尚无定论，但大量的动物证据仍令人担忧。2018 年 4 月 14 日和 15 日，第六届儿科麻醉与神经发育评估（PANDA）研究研讨会在纽约摩根士丹利儿童医院举行。本次研讨会汇集了临床医生和研究人员，为审查与发育中大脑麻醉和神经毒性相关的临床前和临床数据提供了一个平台。该项目的参与者包括许多麻醉神经毒性领域的活跃研究者，以及来自不同背景的利益相关者，他们都对儿童潜在麻醉神经毒性有着共同的兴趣。经过调整的海报会议包括了对临床前动物研究的介绍。这些研究主要集中在定义麻醉诱导的神经毒性表型，了解损伤的机制以及发现潜在的神经毒性作用抑制剂上。
