Department of Anesthesiology, Columbia University, New York, NY.
Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden.
J Neurosurg Anesthesiol. 2019 Jan;31(1):108-114. doi: 10.1097/ANA.0000000000000557.
In the section of "Developmental Neurotoxicity: An Update" of the Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) symposium 2018 the speakers presented the current literature in translational and clinical research. Dr. Brambrink spoke about translational research in anesthetic neurotoxicity, beginning with discovery in the rodent model, then focusing on evidence from nonhuman primates. Dr. Waspe applied the methodology of Adverse Outcome Pathways from the field of toxicology to developmental neurotoxicity of anesthetics. Dr. O'Leary presented relevant clinical studies that were published in 2017 divided by a focus on academic performance, clinical outcomes or diagnoses, or neuropsychological testing.
在 2018 年儿科麻醉神经发育评估 (PANDA) 研讨会的“发育神经毒性：最新进展”部分，演讲者介绍了转化和临床研究的当前文献。Brambrink 博士介绍了麻醉神经毒性的转化研究，从啮齿动物模型的发现开始，然后重点介绍了来自非人类灵长类动物的证据。Waspe 博士将毒理学领域的不良结局途径方法应用于麻醉药物的发育神经毒性。O'Leary 博士介绍了 2017 年发表的相关临床研究，这些研究按关注学术表现、临床结果或诊断或神经心理学测试进行了分类。
