Su Daniel, Obeid Anthony, Hsu Jason
Ophthalmic Surg Lasers Imaging Retina. 2019 Feb 1;50(2):e38-e43. doi: 10.3928/23258160-20190129-17.
Hydration of retinal tissue has been proposed as a potential model of macular hole (MH) formation in addition to tractional forces of the vitreous and internal limiting membrane (ILM). Carbonic anhydrase inhibitors have previously been utilized in the treatment of cystoid macular edema in outer retinal diseases. There has been recent interest in the use of topical aqueous suppression as a potential medical therapy for MHs. In this case series, four eyes with small (< 300 μm) full-thickness MHs were treated with topical dorzolamide-timolol for 1 month. Two eyes achieved closure of the MH without surgical intervention, whereas the other two required pars plana vitrectomy with ILM peel. Future studies are required to investigate the role of topical aqueous suppression in the management of MHs. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e38-e43.].
除了玻璃体和内界膜（ILM）的牵拉力外，视网膜组织水合作用已被提出作为黄斑裂孔（MH）形成的一种潜在模型。碳酸酐酶抑制剂此前已被用于治疗外层视网膜疾病中的黄斑囊样水肿。最近人们对使用局部房水抑制作为MH的一种潜在药物治疗方法产生了兴趣。在这个病例系列中，4只患有小（<300μm）全层MH的眼睛接受了局部多佐胺-噻吗洛尔治疗1个月。2只眼睛在没有手术干预的情况下实现了MH闭合，而另外2只则需要行玻璃体切除术并剥除ILM。需要进一步的研究来探讨局部房水抑制在MH治疗中的作用。[《眼科手术、激光与影像学杂志》。2019年；50：e38-e43。]
