School of Life Science and Technology, ShanghaiTech University, 230 Haike Road, 201210 Shanghai, China.
School of Life Science and Technology, ShanghaiTech University, 230 Haike Road, 201210 Shanghai, China; MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3PT, United Kingdom.
Exp Cell Res. 2019 Mar 15;376(2):159-167. doi: 10.1016/j.yexcr.2019.02.003. Epub 2019 Feb 13.
CTP synthase (CTPsyn) is a metabolic enzyme essential for the de novo synthesis of CTP the nucleotide. CTPsyn can be compartmented into filamentous structures named cytoophidia. Cytoophidia are conserved in a wide range of species and are highly abundant in Drosophila ovaries. Here we report that cytoophidia elongate upon nutrient deprivation, CTPsyn overexpression or heat shock in Drosophila ovaries. We also show that the curvature of cytoophidia changes during apoptosis. Moreover, cytoophidia can be transported from nurse cells to the oocyte via ring canals. Our study demonstrates that cytoophidia can respond to stress and are very dynamic in Drosophila ovaries.
CTP 合酶（CTPsyn）是一种代谢酶，对于从头合成 CTP 核苷酸至关重要。CTPsyn 可以被分隔成丝状结构，称为细胞丝。细胞丝在广泛的物种中保守，并且在果蝇卵巢中高度丰富。在这里，我们报告说，在果蝇卵巢中，细胞丝在营养缺乏、CTPsyn 过表达或热休克时会伸长。我们还表明，细胞丝在细胞凋亡过程中的曲率会发生变化。此外，细胞丝可以通过环管从滋养细胞运输到卵母细胞。我们的研究表明，细胞丝可以对压力做出反应，并且在果蝇卵巢中非常活跃。
