Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rio-verde, San Luis Potosí, Mexico.
Environ Toxicol Pharmacol. 2019 Apr;67:79-86. doi: 10.1016/j.etap.2019.02.004. Epub 2019 Feb 7.
The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 μg/g creatinine was found after urine samples were analyzed (n = 105). Significant associations between UAs levels and serum expression levels of miR-155 (p < 0.05) and miR-126 (p < 0.05) were observed after adjustment for assessed co-variables. Alterations in the serum expression levels of miR-155 and miR-126 may be associated with the onset and development of cardiovascular diseases, hence miRNAs could be proposed as prognostic CVD biomarkers. Data found in this study are of concern and risk reduction plans are necessary for the assessed communities to prevent cardiovascular events in this population of women.
本研究旨在调查三种 miRNA（miR-126、miR-155 和 miR-145）在墨西哥饮用水暴露于无机砷的女性中作为预测 CVD 生物标志物的循环表达水平。对 105 例尿液样本进行分析后发现，尿砷（UAs）浓度的平均值为 19.5±14.0μg/g 肌酐。在调整了评估的协变量后，观察到 UAs 水平与血清 miR-155（p<0.05）和 miR-126（p<0.05）的血清表达水平之间存在显著相关性。miR-155 和 miR-126 血清表达水平的改变可能与心血管疾病的发生和发展有关，因此 miRNA 可被提议作为预测 CVD 的生物标志物。本研究中的数据令人关注，需要为评估的社区制定降低风险计划，以预防该人群的心血管事件。
