Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico; Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Facultad de Enfermería, Universidad Autónoma de Zacatecas, Zacatecas, Zacatecas, Mexico.
Environ Toxicol Pharmacol. 2021 Jan;81:103519. doi: 10.1016/j.etap.2020.103519. Epub 2020 Oct 24.
Cardiovascular diseases (CVDs) are the primary cause of death worldwide. However, little is known about how the interaction between risk factors affects CVDs. Therefore, the aim of this study was to evaluate the effect of the gene-environment interaction (arsenic exposure x PON1 Q192R polymorphism) on serum levels of CVDs biomarkers in Mexican women. Urinary arsenic levels (UAs) ranged from 5.50-145 μg/g creatinine. The allele frequency was 0.38 and 0.62 for the Q and R alleles, respectively. Moreover, significant associations (p<0.05) were detected between UAs and CVDs biomarkers (ADMA, FABP4, and miR-155). Comparable data were found when CVDs biomarkers were evaluated through PON1 genotype, significant (p<0.05) higher serum concentrations of CVDs biomarkers were identified in R allele carriers compared to levels found in Q allele carriers. Besides, a gene-environment interaction was documented. The results of this study we believe should be of significant interest to regulatory authorities worldwide.
心血管疾病 (CVDs) 是全球范围内的主要死亡原因。然而，人们对于危险因素之间的相互作用如何影响 CVDs 知之甚少。因此，本研究旨在评估基因-环境相互作用 (砷暴露 x PON1 Q192R 多态性) 对墨西哥女性 CVDs 生物标志物血清水平的影响。尿砷水平 (UAs) 范围为 5.50-145μg/g 肌酐。等位基因频率分别为 Q 和 R 等位基因的 0.38 和 0.62。此外，还检测到 UAs 与 CVDs 生物标志物 (ADMA、FABP4 和 miR-155) 之间存在显著关联 (p<0.05)。当通过 PON1 基因型评估 CVDs 生物标志物时，发现可比数据，与 Q 等位基因携带者相比，R 等位基因携带者的 CVDs 生物标志物血清浓度显著升高 (p<0.05)。此外，还记录了基因-环境的相互作用。我们认为，本研究的结果应该引起全球监管机构的高度关注。
