Division of Behavioral Genetics, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.
Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, RI, USA.
Addict Biol. 2019 Jan;24(1):132-144. doi: 10.1111/adb.12578. Epub 2017 Nov 27.
Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of complex sociocultural factors, limited research has attempted to examine whether similar genetic variation plays a role across ancestral groups. Using a pooled sample of individuals of African and European ancestry (AA/EA) obtained through data shared within the Database for Genotypes and Phenotypes, we estimated the extent to which additive genetic similarity for AD between AA and EAs using common single nucleotide polymorphisms overlapped across the two populations. AD was represented as a factor score by using Diagnostic and Statistical Manual dependence criteria, and genetic data were imputed by using the 1000 Genomes Reference Panel. Analyses revealed a significant single nucleotide polymorphism-based heritability of 17 percent (SE = 5) in EAs and 24 percent (SE = 15) in AAs. Further, a significant genetic correlation of 0.77 (SE = 0.46) suggests that the allelic architecture influencing the AD factor for EAs and AAs is largely similar across the two populations. Analyses indicated that investigating the genetic underpinnings of alcohol dependence in different ethnic groups may serve to highlight core etiological factors common to both groups and unique etiological factors specific to each ethnic group.
酒精依赖症（AD）影响所有种族/族群的个体，先前的研究表明，在美国，不同祖先定义的群体之间 AD 风险存在相当大的差异。尽管这些差异的原因可能部分归因于复杂的社会文化因素的贡献，但很少有研究试图探讨类似的遗传变异是否在不同祖先群体中发挥作用。本研究使用通过基因型和表型数据库共享获得的非洲和欧洲血统（AA/EA）个体的合并样本，通过使用常见的单核苷酸多态性，来估计 AA 和 EAs 之间 AD 的加性遗传相似性在两个群体中的重叠程度。AD 用诊断和统计手册依赖标准表示为因子得分，遗传数据使用 1000 基因组参考面板进行推断。分析表明，EA 中的单核苷酸多态性遗传率为 17%（SE = 5%），AA 中的遗传率为 24%（SE = 15%）。此外，遗传相关性为 0.77（SE = 0.46），表明影响 EA 和 AA 中 AD 因子的等位基因结构在两个群体中基本相似。分析表明，研究不同种族群体中酒精依赖症的遗传基础，可能有助于突出两个群体共有的核心病因因素和每个群体特有的独特病因因素。
