通过双交叉偶联设计和合成一种新型香蕉状功能分子。

Design and Synthesis of a Novel Banana-Shaped Functional Molecule via Double Cross-Coupling.

机构信息

School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, China.

School of Environmental Science and Engineering, Shandong University, Jinan 250100, China.

出版信息

Molecules. 2019 Feb 15;24(4):698. doi: 10.3390/molecules24040698.

DOI:10.3390/molecules24040698

PMID:30769955

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6412220/

Abstract

A novel banana-shaped molecule using 2,8-Dimethyl-6,12-5,11-methanodibenzo [] [1,5]diazocine (Tröger's base) as bent-core was synthesized via double Carbon-Carbon cross-coupling reaction. The double Sonogashira cross-coupling reaction was optimized by using Pd(PPh₃)₂Cl₂ as catalyst, CuI as cocatalyst and diisopropylamine as base in place of triethylamine. The structure of this compound was confirmed by ¹H-NMR, C-NMR, Fourier transform infrared (FT-IR) spectroscopy and mass spectrometry.

摘要

一种新型的香蕉状分子，使用 2,8-二甲基-6,12-5,11-甲烷二苯并 [] [1,5]二氮杂环（特罗格碱）作为弯曲核，通过双碳-碳交叉偶联反应合成。通过使用 Pd(PPh₃)₂Cl₂作为催化剂、CuI 作为助催化剂和二异丙胺代替三乙胺，优化了双 Sonogashira 交叉偶联反应。通过 ¹H-NMR、C-NMR、傅里叶变换红外（FT-IR）光谱和质谱证实了该化合物的结构。