Division of Immunology, Transplantation and Infectious Diseases and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, 20132, Italy.
Division of Immunology, Transplantation and Infectious Diseases and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, 20132, Italy.
Immunol Lett. 2019 Nov;215:19-23. doi: 10.1016/j.imlet.2019.01.013. Epub 2019 Feb 13.
Type I interferons (IFNs) released upon viral infections play different and opposing roles in disease outcome. This pleiotropic effect is mainly influenced by the cellular sources, timing and target cells for these molecules. The effect of type I IFN signaling on the activation and differentiation of antiviral CD4 T cells remains ill defined, with studies reporting either a beneficial or a detrimental role, depending on the context of infection. This review will highlight several recent studies that have investigated the role of type I IFNs in the priming and polarization of CD4 T cells and discuss areas of uncertainty that require further investigation.
病毒感染时释放的 I 型干扰素（IFNs）在疾病结局中发挥不同且相反的作用。这种多效性效应主要受这些分子的细胞来源、时间和靶细胞影响。I 型 IFN 信号对抗病毒 CD4 T 细胞的激活和分化的影响仍未确定，具体取决于感染的背景，研究报告称其具有有益或有害的作用。这篇综述将重点介绍几项最近的研究，这些研究调查了 I 型 IFNs 在 CD4 T 细胞的启动和极化中的作用，并讨论了需要进一步研究的不确定领域。
