Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China.
Department of Occupational Health and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, 300070, PR China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, 300070, PR China; National Demonstration Center for Experimental Preventive Medicine Education (Tianjin Medical University), Tianjin, 300070, PR China.
Environ Pollut. 2019 May;248:66-73. doi: 10.1016/j.envpol.2019.02.015. Epub 2019 Feb 6.
Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Significantly higher blood concentrations of lead (Pb), cadmium (Cd), copper (Cu), and selenium (Se) were observed in the MetS group. With a priori adjustment for age, the concentration of Cu and Se in the blood was associated with a 2.56 - fold [95% confidence interval (CI), 1.11, 5.92] and 3.31 - fold (95% CI, 1.4, 7.82) increased risk of MetS, respectively. Moreover, increased blood Se concentrations were associated with body mass index (BMI) [odds ratio (OR): 2.56; 95% CI, 1.11, 5.93], high blood pressure [for both systolic and diastolic blood pressures (SBP and DBP); OR: 3.82; 95% CI, 1.47, 7.31 for SBP and OR: 2.56; 95% CI, 1.18, 5.59 for DBP], and hypertriglyceridemia (OR: 3.3; 95% CI, 1.51, 7.2). In addition, the expression of miR-21-5p, miR-122-5p, and miR-146a-5p was significantly higher in subjects with MetS than those without MetS. Increased expression of miR-21-5p was significantly associated with increased SBP (β = 5.28; 95% CI, 0.63, 9.94) and DBP (β = 4.17; 95% CI, 0.68, 7.66). Moreover, Cu was positively associated with miR-21-5p (β = 3.02; 95% CI, 0.07, 5.95), whereas Se was positively associated with miR-122-5p (β = 2.7; 95% CI, 0.64, 4.76). The bootstrapping mediation models indicated that miR-21-5p partially mediated the relationships between Cu level and SBP/DBP. This study suggested that Cu and Se were both associated with MetS, and miR-21-5p participated in the development of MetS associated with Cu.
代谢综合征（MetS）是一个全球性的健康问题，其患病率呈上升趋势。然而，微量元素和重金属对 MetS 的影响及其作用机制尚不清楚。本研究于 2015 年进行了一项初步的横断面研究。结果显示，MetS 组的血液中铅（Pb）、镉（Cd）、铜（Cu）和硒（Se）浓度明显升高。在进行年龄的先验调整后，发现血液中 Cu 和 Se 的浓度与 MetS 的风险分别增加 2.56 倍（95%置信区间 [CI]，1.11，5.92）和 3.31 倍（95%CI，1.4，7.82）。此外，较高的血液 Se 浓度与体重指数（BMI）（比值比 [OR]：2.56；95%CI，1.11，5.93）、高血压（收缩压和舒张压 [SBP 和 DBP]；OR：3.82；95%CI，1.47，7.31 用于 SBP 和 OR：2.56；95%CI，1.18，5.59 用于 DBP）和高甘油三酯血症（OR：3.3；95%CI，1.51，7.2）相关。此外，与无 MetS 相比，MetS 患者的 miR-21-5p、miR-122-5p 和 miR-146a-5p 的表达显著升高。miR-21-5p 的表达增加与 SBP（β=5.28；95%CI，0.63，9.94）和 DBP（β=4.17；95%CI，0.68，7.66）的升高显著相关。此外，Cu 与 miR-21-5p 呈正相关（β=3.02；95%CI，0.07，5.95），而 Se 与 miR-122-5p 呈正相关（β=2.7；95%CI，0.64，4.76）。Bootstrapping 中介模型表明，miR-21-5p 部分介导了 Cu 水平与 SBP/DBP 之间的关系。本研究提示 Cu 和 Se 均与 MetS 相关，miR-21-5p 参与了与 Cu 相关的 MetS 的发生。
