Department of Nutrition, Hygiene and Toxicology, Academy of Nutrition and Health, School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China.
Nutrients. 2023 Jul 19;15(14):3190. doi: 10.3390/nu15143190.
The current study aimed to examine the association between serum selenium levels and lipids and explore whether the association was modified by diabetic status. A total of 4132 adults from the National Health and Nutrition Examination Survey (2011-2016) were included in this study. Multiple linear regression models were used to estimate the association between serum selenium and lipids. Higher serum selenium levels were significantly associated with increased total cholesterol (TC) ( < 0.001), triglyceride (TG) ( = 0.003), and low-density lipoprotein cholesterol (LDL-C) ( = 0.003) in the overall population. Diabetic status interacted with serum selenium for TC and LDL-C ( for interaction = 0.007 and <0.001). Comparing the highest with the lowest tertiles of serum selenium, the multivariate-adjusted β coefficients (95% CIs) were 17.88 (10.89, 24.87) for TC, 13.43 (7.68, 19.18) for LDL-C among subjects without diabetes, but nonsignificant among those with diabetes. In US adults, the serum selenium was positively associated with lipids and the association was modified by diabetic status. Higher serum selenium levels were significantly associated with increased TC and LDL-C among participants without diabetes, but not among participants with diabetes.
本研究旨在探讨血清硒水平与血脂之间的关系，并探讨这种关系是否受糖尿病状态的影响。本研究共纳入了来自国家健康与营养调查（2011-2016 年）的 4132 名成年人。采用多元线性回归模型来估计血清硒与血脂之间的关系。结果表明，在总体人群中，较高的血清硒水平与总胆固醇（TC）（<0.001）、甘油三酯（TG）（=0.003）和低密度脂蛋白胆固醇（LDL-C）（=0.003）呈正相关。糖尿病状态与血清硒对 TC 和 LDL-C 的交互作用（=0.007 和 <0.001）。比较血清硒水平最高和最低三分位数，在无糖尿病的人群中，调整后的多元回归β系数（95%置信区间）分别为 TC 的 17.88（10.89，24.87）和 LDL-C 的 13.43（7.68，19.18），但在糖尿病患者中则无显著差异。在美国成年人中，血清硒与血脂呈正相关，且这种关系受糖尿病状态的影响。在无糖尿病的参与者中，较高的血清硒水平与 TC 和 LDL-C 的增加呈显著相关，但在糖尿病患者中则无显著相关性。
