Hajhashemy Zahra, Foshati Sahar, Bagherniya Mohammad, Askari Gholamreza
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Front Nutr. 2025 Jan 15;11:1451342. doi: 10.3389/fnut.2024.1451342. eCollection 2024.
Although the relationship between selenium and metabolic syndrome (MetS) was previously investigated, the findings were inconsistent. Therefore, we performed a systematic review and dose-response meta-analysis to summarize the association between blood selenium and MetS in adults.
A comprehensive search was conducted in Medline (PubMed), ISI Web of Science, Scopus, and motor engineering of Google Scholar up to October 1st, 2024. Observational studies which reported the risk of MetS in relation to blood selenium in adults were included. The protocol of the current analysis was registered at PROSPERO as CRD42024486035.
Overall, 16,779 participants and 6,471 cases with MetS from 5 cross-sectional and 7 case-control studies were included in the current systematic review and meta-analysis. The findings showed that participants with the highest blood values of selenium (mean: 268.5 μg/L) in comparison to those with the lowest values (mean: 75.27 μg/L) had 40% higher risk of MetS. Nevertheless, this association was not significant (95%CI: 0.99-1.97). Due to a significant between-study heterogeneity (I = 90.4%, < 0.001), subgroup analysis was conducted based on potential confounders. However, this association was only significant in a few subgroups with low number effect sizes. Linear dose-response analysis illustrated each 50 μg/L increment in circulating selenium was related to 7% higher risk of MetS (RR: 1.07, 95%CI: 0.99, 1.15) However, this association was not statistically significant. Additionally, non-linear dose-response analysis indicated a U-shaped association between blood selenium and risk of MetS with the lowest risk at 160 ug/L of blood selenium ( < 0.001).
There is a U-shaped relationship between blood selenium levels risk of MetS. However, more longitudinal studies are needed to verify the causality of findings and clarify the underlying mechanisms.
尽管此前已对硒与代谢综合征（MetS）之间的关系进行了研究，但结果并不一致。因此，我们进行了一项系统评价和剂量反应荟萃分析，以总结成人血液硒与MetS之间的关联。
截至2024年10月1日，在Medline（PubMed）、ISI科学网、Scopus以及谷歌学术的学术引擎中进行了全面检索。纳入了报告成人血液硒与MetS风险关系的观察性研究。本分析方案已在国际前瞻性系统评价注册库（PROSPERO）注册，注册号为CRD42024486035。
总体而言，本系统评价和荟萃分析纳入了来自5项横断面研究和7项病例对照研究的16779名参与者和6471例MetS病例。结果显示，血液硒值最高（平均：268.5μg/L）的参与者与最低值（平均：75.27μg/L）的参与者相比，患MetS的风险高40%。然而，这种关联并不显著（95%CI：0.99 - 1.97）。由于研究间存在显著异质性（I² = 90.4%，P < 0.001），基于潜在混杂因素进行了亚组分析。然而，这种关联仅在少数效应量较小的亚组中显著。线性剂量反应分析表明，循环硒每增加50μg/L与MetS风险增加7%相关（RR：1.07，95%CI：0.99，1.15）。然而，这种关联无统计学意义。此外，非线性剂量反应分析表明血液硒与MetS风险之间呈U形关联，血液硒为160μg/L时风险最低（P < 0.001）。
血液硒水平与MetS风险之间存在U形关系。然而，需要更多的纵向研究来验证研究结果的因果关系并阐明潜在机制。
