一名服用血管紧张素 II 受体阻滞剂的患者溶栓后出现半侧舌部血管性水肿。
Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker.
作者信息
Diestro Jose Danilo Bengzon, Sedano Lady Scarlette Pacsi, Reyes Nikolai Gil Diwa, San Jose Maria Cristina Zarsadias
机构信息
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
出版信息
J Stroke Cerebrovasc Dis. 2019 May;28(5):e44-e45. doi: 10.1016/j.jstrokecerebrovasdis.2019.01.030. Epub 2019 Feb 13.
Orolingual angioedema (OLAE) is a rare adverse effect of alteplase. Previous studies have associated the occurrence of OLAE with thrombolysed patients maintained on angiotensin converting enzyme inhibitors. We report a case of a 60-year-old male presenting with hyperacute ischemic stroke developing hemilingual edema after thrombolysis. He was previously maintained on an angiotensin II receptor blocker (ARB), losartan. The swelling resolved over 2 days with immediate administration of intravenous steroids and antihistamine drugs. Our case is the third documented case of OLAE occurring in a thrombolysed patient concurrently taking an ARB. The presence of hemilingual edema in a post-thrombolysis patient maintained on losartan suggests a possible association between OLAE and ARBs.
口咽血管性水肿（OLAE）是阿替普酶罕见的不良反应。既往研究将OLAE的发生与接受血管紧张素转换酶抑制剂治疗的溶栓患者联系起来。我们报告一例60岁男性，因超急性缺血性卒中接受溶栓治疗后出现半侧舌水肿。他之前一直在服用血管紧张素II受体阻滞剂（ARB）氯沙坦。静脉立即给予类固醇和抗组胺药物后，肿胀在2天内消退。我们的病例是第三例记录在案的在接受溶栓治疗的同时服用ARB的患者发生OLAE的病例。在接受氯沙坦治疗的溶栓后患者中出现半侧舌水肿提示OLAE与ARB之间可能存在关联。
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