Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil.
Doctorate in the Program of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, Brazil.
Steroids. 2019 May;145:19-22. doi: 10.1016/j.steroids.2019.02.011. Epub 2019 Feb 15.
Testosterone cypionate and Stanozolol are Anabolic-Androgenic Steroids (AAS) which are synthetic substances that possess functions similar to testosterone. The use of these substances has increased considerably among youngsters and sports practitioners aiming better performance of with aesthetic purposes. The major concern is the effects caused by the inappropriate use of the substances, such as hypertension, myocardial ischemia, and left ventricle hypertrophy. The objective of the present research was to measure the diameter of the left ventricle lumen and the thickness of the left ventricle myocardium in mice submitted to supraphysiological doses of AAS. A total of 30 female Swiss mice were used in the experiments. The animals received supraphysiological doses of the AAS for 30 days, and during the treatment period, they were put to swim in intercalated days. After treatment animals were euthanized and slides were made from the hearts for measurements. Results demonstrated that both AAS changed significantly the heart morphology: Testosterone cypionate led to an increase in the ventricular lumen and stanozolol increased left ventricle myocardium thickness. In conclusion, the use of AAS in supraphysiological doses can change the heart morphology and can lead to serious health consequences.
睾酮 Cypionate 和司坦唑醇是合成代谢雄激素类固醇（AAS），它们具有与睾酮相似的功能。这些物质的使用在年轻人和运动从业者中大量增加，目的是提高表现和审美效果。主要关注点是这些物质的不当使用引起的影响，如高血压、心肌缺血和左心室肥大。本研究的目的是测量接受超生理剂量 AAS 的小鼠的左心室管腔直径和左心室心肌厚度。共使用了 30 只雌性瑞士小鼠进行实验。动物接受超生理剂量的 AAS 治疗 30 天，在治疗期间，它们被安排在间歇日游泳。治疗结束后，处死动物并从心脏制作切片进行测量。结果表明，两种 AAS 都显著改变了心脏形态：睾酮 Cypionate 导致心室管腔增大，司坦唑醇增加了左心室心肌厚度。总之，超生理剂量使用 AAS 会改变心脏形态，并可能导致严重的健康后果。
