Clark A S, Blasberg M E, Brandling-Bennett E M
Department of Psychology, Dartmouth College, Hanover, NH 03755, USA.
Physiol Behav. 1998 Jan;63(2):287-95. doi: 10.1016/s0031-9384(97)00443-5.
Anabolic-androgenic steroid (AAS) effects on the estrous cycle of adult Long-Evans rats were examined in four different experiments. Sexual receptivity, vaginal cytology, and body weight were monitored throughout two-week baseline, AAS treatment, and recovery periods. In Experiments 1-3, rats were administered stanozolol, oxymetholone, or testosterone cypionate within dose ranges selected to mimic the human abuse levels of each compound. In these studies, the highest doses of stanozolol (5 mg/kg), oxymetholone (12 mg/kg), or testosterone cypionate (7.5 mg/kg) disrupted the cyclical display of sexual receptivity and vaginal estrus. To compare effects on estrous cyclicity across AAS compounds, rats in Experiment 4 received a single dose (7.5 mg/kg) of each compound for 2 weeks. At the 7.5 mg/kg dose, all AAS compounds interfered with the cyclical display of vaginal estrus, although effects on sexual receptivity were not uniform. No striking AAS effects on body weight were seen in any experiment. The short-term administration of AAS compounds at high doses disrupts female neuroendocrine function in rats.
在四项不同实验中研究了合成代谢雄激素类固醇（AAS）对成年Long-Evans大鼠发情周期的影响。在为期两周的基线期、AAS治疗期和恢复期全程监测性接受能力、阴道细胞学和体重。在实验1-3中，给大鼠施用司坦唑醇、羟甲烯龙或环戊丙酸睾酮，剂量范围选择为模拟每种化合物的人类滥用水平。在这些研究中，司坦唑醇（5毫克/千克）、羟甲烯龙（12毫克/千克）或环戊丙酸睾酮（7.5毫克/千克）的最高剂量破坏了性接受能力和阴道发情的周期性表现。为了比较不同AAS化合物对发情周期的影响，实验4中的大鼠接受每种化合物单剂量（7.5毫克/千克），持续2周。在7.5毫克/千克剂量下，所有AAS化合物均干扰了阴道发情的周期性表现，尽管对性接受能力的影响并不一致。在任何实验中均未观察到AAS对体重有显著影响。高剂量短期施用AAS化合物会破坏大鼠的雌性神经内分泌功能。
