Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Department of Microbiology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Int J Infect Dis. 2019 Apr;81:110-113. doi: 10.1016/j.ijid.2019.02.002. Epub 2019 Feb 14.
We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy.
我们报告了首例三岁急性淋巴细胞白血病合并诱导化疗期发热性中性粒细胞减少症患儿，经超声引导下抽吸液聚合酶链反应（PCR）扩增核酸检测到微脓肿的病例。尽管进行了有效的抗真菌治疗，但患儿仍持续发热。加用皮质类固醇治疗成功控制了疑似免疫重建炎症综合征（IRIS）。该病例强调了 PCR 和辅助皮质类固醇在化疗的白血病患者中治疗热带念珠菌肾微脓肿的应用价值。
