Srivastava K C
Biomed Biochim Acta. 1984;43(8-9):S335-46.
Aqueous extracts of onion, garlic and ginger inhibited platelet aggregation induced by several aggregation agents, including arachidonate (AA), in a dose-dependent manner. While onion and garlic extracts were found to be weak inhibitors of platelet thromboxane synthesis, ginger extract inhibited the platelet cyclooxygenase products and this effect correlated well with its inhibitory effects on the platelet aggregation induced by the above aggregation agents. These two effects were dose-dependent. Although the three aqueous extracts inhibited the biosynthesis of 6-keto-F1 alpha in rat aortic rings from labelled AA, they did not reduce prostacyclin production from endogenous AA pool in aortic rings. Aqueous ginger extract was extracted into three organic solvents in order of increasing polarity (n-hexane, chloroform, ethyl acetate). An analysis of the n-hexane extract revealed at least three clearly separated TLC bands containing materials that inhibited platelet thromboxane generation simultaneously increasing lipoxygenase products (HETE). The results indicate that if the same were happening in vivo, onion, garlic and ginger could be useful as natural antithrombotic materials.
洋葱、大蒜和生姜的水提取物以剂量依赖的方式抑制了由多种聚集剂（包括花生四烯酸（AA））诱导的血小板聚集。虽然发现洋葱和大蒜提取物是血小板血栓素合成的弱抑制剂，但生姜提取物抑制了血小板环氧化酶产物，并且这种作用与其对上述聚集剂诱导的血小板聚集的抑制作用密切相关。这两种作用均呈剂量依赖性。尽管这三种水提取物抑制了来自标记AA的大鼠主动脉环中6-酮-F1α的生物合成，但它们并未减少主动脉环中内源性AA池产生的前列环素。将生姜水提取物依次用三种极性递增的有机溶剂（正己烷、氯仿、乙酸乙酯）进行萃取。对正己烷提取物的分析显示，至少有三个明显分离的薄层色谱带，其中含有的物质在抑制血小板血栓素生成的同时增加了脂氧合酶产物（羟二十碳四烯酸）。结果表明，如果体内发生同样的情况，洋葱、大蒜和生姜可能作为天然抗血栓物质发挥作用。
