Prabahar Kousalya, Katikam Teja, Punniyakotti Saranya, Devanandan Praveen
Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Kingdom of Saudi Arabia.
Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.
Pak J Pharm Sci. 2019 Jan;32(1):213-215.
To evaluate the anti-hypertensive drugs used in pregnancy induced hypertension and to determine the safety of the anti-hypertensive drugs administered in gestational hypertensive patients. Pregnancy induced hypertension are very common in women and if unnoticed may lead to severe complications. The appropriate therapy is very much essential for the welfare of both the mother and the child. Hence this study was undertaken to identify the commonly used and safe drugs in pregnancy induced hypertension. This retrospective study was carried out in the Medical Records Department of a specialized gynecological hospital. Patient details - Name, Age, Sex, Occupation, Body Mass Index (BMI), Social History (SH), Past Medical History (PMH), Diagnosis, mother weight and BP, baby weight, specific anti-hypertensives given, outcome, complication in both mother and baby if any, duration of anti-hypertensive drug use, duration of hospital stay were all recorded in a proforma. Adverse Drug Reactions for anti-hypertensive drugs given were also noted. Nifedipine was the most common drug prescribed both in monotherapy and dual therapy. Adverse drug reaction was seen only in 2% of patients. Pregnancy induced hypertension is one of the riskiest conditions to occur during pregnancy. Dietary modification and lifestyle modification might help in controlling pre-eclampsia.
评估用于妊娠高血压综合征的降压药物,并确定在妊娠高血压患者中使用的降压药物的安全性。妊娠高血压综合征在女性中非常常见,如果不加以注意可能会导致严重并发症。适当的治疗对于母亲和孩子的健康都至关重要。因此,开展这项研究以确定妊娠高血压综合征中常用且安全的药物。这项回顾性研究在一家专业妇科医院的病历科进行。患者详细信息——姓名、年龄、性别、职业、体重指数(BMI)、社会史(SH)、既往病史(PMH)、诊断、母亲体重和血压、婴儿体重、给予的特定降压药、结局、母亲和婴儿是否有并发症(如有)、降压药使用时长、住院时长均记录在一份表格中。还记录了所给予降压药物的药物不良反应。硝苯地平是单药治疗和联合治疗中最常用的药物。仅2%的患者出现药物不良反应。妊娠高血压综合征是孕期发生的最危险情况之一。饮食调整和生活方式改变可能有助于控制先兆子痫。