Department of Dermatology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Department of Surgery, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Biochem Biophys Res Commun. 2019 Mar 26;511(1):105-110. doi: 10.1016/j.bbrc.2019.02.050. Epub 2019 Feb 14.
Aristaless-like homeobox1 (ALX1), a member of the ALX family, is capable of mediating survival and development of mesenchyme-derived elements in vertebrates and its mutation will prevent the fusion of frontonasal and maxillary elements. Recently, ALX1 has been reported to be associated with cancer progression. However, the specific roles of ALX1 in melanoma remain unclear. In this study, we investigated the expression pattern and biological functions of ALX1 in melanoma. We found that ALX1 was highly expressed in melanoma tissues and cell lines. Knockdown of ALX1 suppressed the proliferation and invasion of melanoma cells. Furthermore, we showed that ALX1 knockdown reversed the epithelial-mesenchymal transition (EMT) process in melanoma cells, which might be attributed to inactivation of the Wnt/β-catenin pathway. Taken together, this study provided a new insight into the role of ALX1 as a therapeutic target for melanoma treatment.
类 Aristaless 同源盒蛋白 1（ALX1）是 ALX 家族的一员，能够介导脊椎动物中中胚层来源的元素的存活和发育，其突变将阻止额鼻和上颌元素的融合。最近，ALX1 已被报道与癌症进展有关。然而，ALX1 在黑色素瘤中的具体作用尚不清楚。在这项研究中，我们研究了 ALX1 在黑色素瘤中的表达模式和生物学功能。我们发现 ALX1 在黑色素瘤组织和细胞系中高度表达。敲低 ALX1 抑制了黑色素瘤细胞的增殖和侵袭。此外，我们表明，ALX1 敲低逆转了黑色素瘤细胞的上皮-间充质转化（EMT）过程，这可能归因于 Wnt/β-catenin 通路的失活。总之，这项研究为 ALX1 作为黑色素瘤治疗的治疗靶点提供了新的见解。
