Yao Wei, Liu Yong, Zhang Zhuo, Li Guoquan, Xu Xiaoying, Zou Kun, Xu Yinghui, Zou Lijuan
Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Dalian Medical University, Graduate School of Dalian Medical University Dalian 116027, China.
The First Affiliated Hospital of Dalian Medical University Dalian 116011, China.
Int J Clin Exp Pathol. 2015 Oct 1;8(10):12129-39. eCollection 2015.
Lung cancer is one of the main causes in cancer-related death. Here we reported a novel functional role of Aristaless-like homeobox1 (ALX1) in lung carcinogenesis. Analysis of ALX1 in lung cancer specimens confirms upregulation of ALX1 in lung cancer, especially these with distant metastasis. Moreover, higher level of ALX1 expression is associated with poorer prognosis of lung cancer patients. Ectopic expression of ALX1 significantly promotes lung cancer cell proliferation, migration and invasion, while ALX1 silencing by siRNA significantly inhibits these abilities of lung cancer cells. The functional role of ALX1 is dependent on increasing Snail expression and knockdown of Snail could restrain the role of ALX1. Collectively, we identify critical roles of ALX1 in lung cancer development and progression. These findings may serve as a framework for future investigations designed to more comprehensive determination of ALX1 as a potential therapeutic target.
肺癌是癌症相关死亡的主要原因之一。在此，我们报道了无尾样同源框1（ALX1）在肺癌发生中的一种新的功能作用。对肺癌标本中ALX1的分析证实，ALX1在肺癌中上调，尤其是在那些发生远处转移的肺癌中。此外，较高水平的ALX1表达与肺癌患者较差的预后相关。ALX1的异位表达显著促进肺癌细胞的增殖、迁移和侵袭，而通过小干扰RNA（siRNA）使ALX1沉默则显著抑制肺癌细胞的这些能力。ALX1的功能作用依赖于Snail表达的增加，敲低Snail可抑制ALX1的作用。总体而言，我们确定了ALX1在肺癌发展和进展中的关键作用。这些发现可能为未来旨在更全面确定ALX1作为潜在治疗靶点的研究提供一个框架。
