Center for Brain Health, New York University School of Medicine, Department of Psychiatry, 145 East 32nd Street, New York, NY 10016, United States of America.
Center for Brain Health, New York University School of Medicine, Department of Psychiatry, 145 East 32nd Street, New York, NY 10016, United States of America.
Epilepsy Behav. 2019 May;94:297-300. doi: 10.1016/j.yebeh.2019.01.022. Epub 2019 Feb 14.
Depression affects a large proportion of patients with epilepsy, and is likely due in part to biological mechanism. Hormonal dysregulation due to the disruptive effects of seizures and interictal epileptiform discharges on the hypothalamic-pituitary-adrenal axis likely contributes to high rates of depression in epilepsy. This paper reviews the largely unexplored role of neuroendocrine factors in epilepsy-related depression, focusing on Growth Hormone (GH). While GH deficiency is traditionally considered a childhood disorder manifested by impaired skeletal growth, GH deficiency in adulthood is now recognized as a serious disorder characterized by impairments in multiple domains including mood and quality of life. Could high rates of depression in patients with epilepsy relate to subtle GH deficiency? Because GH replacement therapy has been shown to improve mood and quality of life in patients with GH deficiency, this emerging area may hold promise for patients suffering from epilepsy-related depression.
抑郁症影响了很大比例的癫痫患者,部分原因可能与生物学机制有关。癫痫发作和发作间期痫性放电对下丘脑-垂体-肾上腺轴的破坏作用导致的激素失调,可能导致癫痫患者中出现高比例的抑郁症。本文综述了神经内分泌因素在癫痫相关抑郁症中的作用,重点介绍了生长激素(GH)。虽然生长激素缺乏症传统上被认为是一种儿童疾病,表现为骨骼生长受损,但现在已认识到成人中的生长激素缺乏症是一种严重疾病,其特征是包括情绪和生活质量在内的多个领域受损。癫痫患者中高比例的抑郁症是否与轻微的生长激素缺乏有关?由于生长激素替代疗法已被证明可改善生长激素缺乏症患者的情绪和生活质量,因此这个新兴领域可能为患有癫痫相关抑郁症的患者带来希望。