Shibata Yoko, Inoue Sumito, Watanabe Masafumi
Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima, Japan.
Department of Cardiology, Pulmonology and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.
Respir Investig. 2019 May;57(3):220-226. doi: 10.1016/j.resinv.2019.01.005. Epub 2019 Feb 14.
Regional epidemiological studies for respiratory diseases have been rarely performed in Japan, because spirometry is not regularly conducted in the standard annual health checks. The Yamagata-Takahata Study is an epidemiological study utilizing regional characteristics based on the 21st Century Centers of Excellence (COE) Program and the Global COE Program. Spirometric examination and other specific measurements via blood sampling were performed for the study participants in annual health check-ups held in Takahata, a town in Yamagata Prefecture. The Yamagata-Takahata Study revealed the impact of cigarette smoking habit on pulmonary function, the impact of reduced pulmonary function on mortality, and the situation regarding COPD comorbidities in Japan. Additionally, the study identified biomarkers of decline in pulmonary function among active smokers, and the risk factors for respiratory mortality in Japan. In this review, we summarize the findings of the Yamagata-Takahata study regarding the association between lower pulmonary function and the clinical characteristics of a Japanese general population.
在日本，针对呼吸系统疾病的区域流行病学研究很少开展，因为肺活量测定并未常规纳入标准年度健康检查中。山形 - 高畑研究是一项基于21世纪卓越中心（COE）计划和全球COE计划利用区域特征开展的流行病学研究。通过在山形县高畑町举行的年度健康检查中，对研究参与者进行肺活量测定检查以及其他通过血液采样进行的特定测量。山形 - 高畑研究揭示了吸烟习惯对肺功能的影响、肺功能下降对死亡率的影响以及日本慢性阻塞性肺疾病（COPD）合并症的情况。此外，该研究还确定了现吸烟者肺功能下降的生物标志物以及日本呼吸死亡率的风险因素。在本综述中，我们总结了山形 - 高畑研究中关于肺功能降低与日本普通人群临床特征之间关联的研究结果。
