日本普通人群血浆脂联素水平与1秒用力呼气量下降之间的关联：高幡研究
Association between plasma adiponectin levels and decline in forced expiratory volume in 1 s in a general Japanese population: the Takahata study.
作者信息
Sato Kento, Shibata Yoko, Abe Shuichi, Inoue Sumito, Igarashi Akira, Yamauchi Keiko, Aida Yasuko, Nunomiya Keiko, Nakano Hiroshi, Sato Masamichi, Kimura Tomomi, Nemoto Takako, Watanabe Tetsu, Konta Tsuneo, Ueno Yoshiyuki, Kato Takeo, Kayama Takamasa, Kubota Isao
机构信息
1. Department of Cardiology, Pulmonology, and Nephrology;
2. Global Center of Excellence Program Study Group, Yamagata University School of Medicine, 2-2-2 Iida-Nishi Yamagata 990-9585, Japan.
出版信息
Int J Med Sci. 2014 May 21;11(8):758-64. doi: 10.7150/ijms.8919. eCollection 2014.
BACKGROUND
Adiponectin is an anti-inflammatory and cardio-protective cytokine. However, several studies have demonstrated that plasma adiponectin levels were inversely associated with pulmonary function in patients with chronic obstructive pulmonary disease, suggesting a proinflammatory or pulmonary-destructive role. It is still unclear whether adiponectin is a potent biomarker predicting declines in pulmonary function. The aim of this study was to investigate the association between adiponectin and pulmonary function among Japanese individuals who participated in an annual health check-up.
METHODS
Spirometry and blood sampling, including measurements of plasma adiponectin, were performed for 3,253 subjects aged 40 years or older who participated in a community-based annual health check-up in Takahata, Japan from 2004 to 2006. In 2011, spirometry was re-performed, and the data from 872 subjects (405 men and 467 women) were available for a longitudinal analysis.
RESULTS
Plasma adiponectin levels were found to be significantly associated with age, body mass index (BMI), and alanine aminotransferase (ALT), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-c) levels among both men and women in the study population. Plasma adiponectin levels were found to be associated with lifetime cigarette consumption (Brinkman index, BI) in men only. Plasma adiponectin levels were inversely correlated with forced expiratory volume in 1 s (FEV1) per forced vital capacity in both men and women. In addition, the annual change in FEV1 was inversely associated with plasma adiponectin levels in both genders. A multiple linear regression analysis revealed that this association was independent of other confounding factors such as age, BMI, BI, ALT, TG, and HDL-c.
CONCLUSIONS
The results of the present study suggest that adiponectin levels are predictive of declines in FEV1 in the general population.
背景
脂联素是一种抗炎和心脏保护细胞因子。然而，多项研究表明，慢性阻塞性肺疾病患者的血浆脂联素水平与肺功能呈负相关，提示其具有促炎或肺破坏作用。脂联素是否是预测肺功能下降的有效生物标志物仍不清楚。本研究的目的是调查参加年度健康检查的日本人群中脂联素与肺功能之间的关联。
方法
对2004年至2006年在日本高幡参加社区年度健康检查的3253名40岁及以上的受试者进行了肺活量测定和血液采样，包括血浆脂联素的测量。2011年，再次进行肺活量测定，872名受试者（405名男性和467名女性）的数据可用于纵向分析。
结果
在研究人群中，男性和女性的血浆脂联素水平均与年龄、体重指数（BMI）、丙氨酸转氨酶（ALT）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-c）水平显著相关。仅在男性中发现血浆脂联素水平与终生吸烟量（布林克曼指数，BI）有关。男性和女性的血浆脂联素水平与1秒用力呼气量（FEV1）占用力肺活量的比例均呈负相关。此外，FEV1的年度变化在两性中均与血浆脂联素水平呈负相关。多元线性回归分析显示，这种关联独立于年龄、BMI、BI、ALT、TG和HDL-c等其他混杂因素。
结论
本研究结果表明，脂联素水平可预测普通人群中FEV1的下降。
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