School of Chemical Engineering, Sungkyunkwan University (SKKU), Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.
SKKU Advanced Institute of Nanotechnology (SAINT), Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University (SKKU), Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.
Adv Mater. 2019 Aug;31(34):e1803309. doi: 10.1002/adma.201803309. Epub 2019 Feb 18.
The attachment phenomena of various hierarchical architectures found in nature have extensively drawn attention for developing highly biocompatible adhesive on skin or wet inner organs without any chemical glue. Structural adhesive systems have become important to address the issues of human-machine interactions by smart outer/inner organ-attachable devices for diagnosis and therapy. Here, advances in designs of biologically inspired adhesive architectures are reviewed in terms of distinct structural properties, attachment mechanisms to biosurfaces by physical interactions, and noteworthy fabrication methods. Recent demonstrations of bioinspired adhesive architectures as adhesive layers for medical applications from skin patches to multifunctional bioelectronics are presented. To conclude, current challenges and prospects on potential applications are also briefly discussed.
附件中的各种分层结构现象在自然界中广泛存在，这为开发高度生物相容性的皮肤或湿润内器官粘合剂提供了灵感，而无需使用任何化学胶。结构型粘合剂系统对于通过智能外/内器官附着设备来解决人机交互问题，从而实现诊断和治疗变得越来越重要。在此，从物理相互作用的生物表面附着机制和显著的制造方法等方面，综述了受生物启发的各种粘合结构设计的进展。本文还介绍了生物启发型粘合结构作为医疗应用的粘合层的最新进展，从皮肤贴片到多功能生物电子学。最后，还简要讨论了当前面临的挑战和潜在应用的前景。
