一系列不饱和二硫化物对A549肺癌细胞抗癌活性的合成及初步评价
Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides.
作者信息
Olivito Fabrizio, Amodio Nicola, Di Gioia Maria Luisa, Nardi Monica, Oliverio Manuela, Juli Giada, Tassone Pierfrancesco, Procopio Antonio
机构信息
Dipartimento di Scienze della Salute , Università Magna Græcia , Viale Europa, Germaneto , Catanzaro , 88100 , Italy . Email:
Dipartimento di Chimica , Università della Calabria , Cubo 12C, Arcavacata di Rende , Cosenza , 87030 , Italy.
出版信息
Medchemcomm. 2018 Dec 5;10(1):116-119. doi: 10.1039/c8md00503f. eCollection 2019 Jan 1.
Abstract
We synthesized a series of small symmetrical unsaturated disulfides by a multi-step reaction starting from organic alcohols, and we performed a preliminary test to evaluate the effect of these compounds on the viability of A549 lung cancer cells. The garlic-derived natural compound diallyl disulfide, known for its anticancer activity, was used as the lead compound in this study. We synthesized five DADS analogues having different carbon chain lengths and different positions of the double bonds. Two analogues exhibited a promising antitumor activity , and the allylic double bond did not seem to be the main driving force.
摘要
我们从有机醇开始，通过多步反应合成了一系列小型对称不饱和二硫化物，并进行了初步测试，以评估这些化合物对A549肺癌细胞活力的影响。大蒜衍生的天然化合物二烯丙基二硫化物以其抗癌活性而闻名，在本研究中用作先导化合物。我们合成了五种具有不同碳链长度和双键不同位置的二烯丙基二硫化物类似物。两种类似物表现出有前景的抗肿瘤活性，并且烯丙基双键似乎不是主要驱动力。
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