脂双层中的抗氧化剂生成和再生：亲脂性硫代亚磺酸酯和亲水性硫醇的惊人情况。
Antioxidant generation and regeneration in lipid bilayers: the amazing case of lipophilic thiosulfinates and hydrophilic thiols.
机构信息
Department of Chemistry, University of Ottawa, 10 Marie Curie Pvt., Ottawa, Ontario, Canada.
出版信息
Chem Commun (Camb). 2013 Sep 25;49(74):8181-3. doi: 10.1039/c3cc44401e.
PMID:23938951
Abstract
We demonstrate that the garlic-derived chemopreventive agent allicin and the related anamu-derived petivericin are poor radical-trapping antioxidants in lipid bilayers, but that the in situ reaction of a lipophilic analog and a hydrophilic thiol yields an extremely potent radical-trapping antioxidant that can be recycled in the presence of excess thiol.
摘要
我们证明，大蒜衍生的化学预防剂蒜素和相关的安纳姆衍生的佩替维丁在脂质双层中是较差的自由基捕获抗氧化剂，但亲脂性类似物和亲水性硫醇的原位反应产生了一种极其有效的自由基捕获抗氧化剂，在过量硫醇存在下可以回收。
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