Zhang Penghao, Lu Bingyu, Sun Yanwen, Yu Haixia, Xu Kexin, Li Dachao
State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, 300072, China.
Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University, 300072, China.
Biomed Opt Express. 2018 Dec 17;10(1):215-225. doi: 10.1364/BOE.10.000215. eCollection 2019 Jan 1.
Fiber-based techniques make it possible to implant a miniaturized and flexible surface plasmon resonance (SPR) sensor into the human body. However, for implantable applications, the miniaturization of fiber SPR sensors results in low sensitivity compared with traditional prism-type SPR sensors due to limited space and the effects of temperature fluctuations. Therefore, it is necessary to compensate for temperature drift in the measurements, such as the case of the quantification of the relationship between glucose concentration and SPR resonance wavelength. In this report, we proposed a highly sensitive fiber SPR sensor based on a side-polished structure modified by graphene for implantable continuous glucose monitoring with temperature self-compensation using a long-period fiber grating (LPFG). The results demonstrate that the sensor with monolayer graphene achieved the best sensitivity of 3058.22 nm/RIU, and the LPFG achieves a maximum resolution of 0.042 nm/°C. The proposed SPR sensor enabled the detection of hypoglycemia, which is still a significant challenge for continuous glucose monitoring in a clinical setting.
基于光纤的技术使得将小型化且灵活的表面等离子体共振（SPR）传感器植入人体成为可能。然而，对于可植入应用而言，与传统棱镜型SPR传感器相比，光纤SPR传感器的小型化由于空间有限以及温度波动的影响，导致灵敏度较低。因此，有必要在测量中补偿温度漂移，比如在量化葡萄糖浓度与SPR共振波长之间关系的情况下。在本报告中，我们提出了一种基于经石墨烯修饰的侧面抛光结构的高灵敏度光纤SPR传感器，用于通过长周期光纤光栅（LPFG）进行具有温度自补偿功能的可植入式连续血糖监测。结果表明，具有单层石墨烯的传感器实现了3058.22 nm/RIU的最佳灵敏度，并且LPFG实现了0.042 nm/°C的最大分辨率。所提出的SPR传感器能够检测低血糖，这对于临床环境中的连续血糖监测而言仍是一项重大挑战。
