Schmelzeisen-Redeker Günther, Staib Arnulf, Strasser Monika, Müller Ulrich, Schoemaker Michael
Roche Diagnostics, Mannheim, Germany.
J Diabetes Sci Technol. 2013 Jul 1;7(4):808-14. doi: 10.1177/193229681300700402.
The core element of a continuous glucose monitoring (CGM) system is the glucose sensor, which should enable reliable CGM readings in the interstitial fluid in subcutaneous tissue for a period of several days. The aim of this article is to describe the layout and constituents of a novel glucose sensor and the rationale behind the measures that were used to optimize its performance. In order to achieve a stable glucose sensor signal, special attention was paid to the sensor materials and architecture, i.e., biocompatible coating of the sensor, limitation of glucose flux into the working electrode, low oxidation potential by use of manganese dioxide, and a tissue-averaging sensor design. A series of in vitro and in vivo evaluations showed that the sensor enables stable and accurate glucose sensing in the subcutaneous tissue for up to 7 days. Parallel measurements with four sensors in a single patient showed a close agreement between these sensors. In summary, this high-performance needle-type glucose sensor is well suited for CGM in patients with diabetes.
连续血糖监测（CGM）系统的核心元件是葡萄糖传感器，该传感器应能够在皮下组织的间质液中实现数天的可靠CGM读数。本文旨在描述一种新型葡萄糖传感器的布局和组成部分，以及用于优化其性能的措施背后的原理。为了获得稳定的葡萄糖传感器信号，特别关注了传感器材料和结构，即传感器的生物相容性涂层、限制葡萄糖流入工作电极、使用二氧化锰降低氧化电位以及组织平均传感器设计。一系列体外和体内评估表明，该传感器能够在皮下组织中实现长达7天的稳定且准确的葡萄糖传感。在一名患者体内同时使用四个传感器进行的平行测量显示，这些传感器之间具有高度一致性。总之，这种高性能针型葡萄糖传感器非常适合糖尿病患者的CGM。
