Zani Donatella De, Rabbogliatti Vanessa, Ravasio Giuliano, Pettinato Cinzia, Giancamillo Mauro Di, Zani Davide Danilo
Dipartimento di Medicina Veterinaria, Centro Clinico Veterinario e Zootecnico Sperimentale, Università degli Studi di Milano, Italy.
Department of Medical Physics, Policlinico S.Orsola-Malpighi, Bologna, Italy.
Open Vet J. 2018;8(4):471-478. doi: 10.4314/ovj.v8i4.19. Epub 2018 Dec 15.
The use of contrast enhanced magnetic resonance imaging (MRI) for the detection of orthopedic pathologies in equine patients is poorly described. In few studies, enhanced MRI allowed to differentiate active lesions from chronic ones and to classify ambiguous lesions. The aim of this clinical prospective pilot study is to describe and compare the MRI lesions observed in horses with lameness localized to the foot using a single intravenous bolus dose of gadolinium contrast versus regional intraarterial bolus of contrast agent. Ten horses that underwent contrast enhanced MRI were included in the study. Gadolinium was injected intravenously in 3 patients and in 7 horses contrast agent was administered by intraarterial regional delivery. Regions of interest (ROI) were collected from both pre- and post-contrast images and ratios between pre- and post-contrast ROIs were calculated. No adverse reactions were noted after contrast agent injection. Injured structures that revealed greater increase in signal in post-contrast images were the deep digital flexor tendon (DDFT), the navicular spongiosa and the peritendinous tissues. Regional intraarterial administration of gadolinium provided higher ratio of contrast enhancement. Enhanced MRI using both intravenous or intraarterial injection of gadolinium, increased the diagnostic capability of MRI in horses with foot lesions. Nevertheless, regional intraarterial administration of gadolinium was considered the best choice due to the higher signal and lower volumes of contrast agent required.
对比增强磁共振成像（MRI）在马属动物患者中用于检测骨科病变的应用描述较少。在少数研究中，增强MRI能够区分活动性病变和慢性病变，并对不明确的病变进行分类。这项临床前瞻性试点研究的目的是描述和比较使用单次静脉推注钆对比剂与区域动脉内推注对比剂在足部跛行马匹中观察到的MRI病变。10匹接受对比增强MRI的马被纳入研究。3匹马静脉注射钆，7匹马通过动脉内区域给药给予对比剂。从对比前和对比后的图像中采集感兴趣区域（ROI），并计算对比前和对比后ROI之间的比率。注射对比剂后未观察到不良反应。在对比后图像中信号增强更明显的损伤结构是指深屈肌腱（DDFT）、舟骨海绵体和腱周组织。钆的区域动脉内给药提供了更高的对比增强率。静脉或动脉内注射钆的增强MRI提高了MRI对足部病变马匹的诊断能力。然而，由于所需的对比剂信号更高且体积更小，钆的区域动脉内给药被认为是最佳选择。
