Kuwabara Akiko, Tsugawa Naoko, Kondo Hiroshi, Ao Misora, Fujiwara Hitomi, Hosokawa Natsuki, Matsumoto Shiho, Tanaka Kiyoshi, Nakano Tetsuo
Department of Health and Nutrition, Osaka Shoin Women's University, 4-2-26 Hishiyanishi, Higashiosaka, Osaka 577-8550, Japan.
Department of Orthopaedic Surgery, Tamana Central Hospital, 1950 Naka, Tamana, Kumamoto, 865-0064, Japan.
Osteoporos Sarcopenia. 2017 Mar;3(1):53-58. doi: 10.1016/j.afos.2017.02.002. Epub 2017 Mar 7.
One of the important risk factors of falling is decreased muscle mass and muscle strength. Recently, there has been an increasing concern on the role of vitamin D in muscle strength and physical activity. Aim of our study is to examine the relationships between vitamin D status and muscle mass and muscle strength in middle-aged healthy adults.
Subjects were 40 healthy volunteers aged 42.0 ± 10.6 years old. Evaluation was made for serum vitamin D metabolites including 25-hydroxyvitamin D [25(OH)D] and 24,25-dihydroxyvitamin D [24,25(OH)D] concentrations, lower limb muscle strength, and dietary intake by food frequency questionnaire. Body composition was measured by dual-energy X-ray absorptiometry (DXA), and appendicular skeletal mass index (ASMI) was calculated as skeletal muscle mass/squared height.
70% of the subjects had vitamin D insufficiency/deficiency (serum total 25(OH)D < 20 ng/mL), and female subjects had significantly lower serum total 25(OH)D level compared with males. Vitamin D insufficiency/deficiency group had significantly higher body fat, lower SMI and muscle strength, probably reflecting higher percentage of female subjects. Serum vitamin D metabolites levels were significantly correlated with whole and site-specific ASMI, and lower limb muscle strength, except for the correlation between serum 24,25(OH)D concentration and lower limb muscle strength. In addition, serum 25(OH)D level was a positive significant predictor for both ASMI and lower limb muscle strength, while serum 24,25(OH)D level was not their significant predictor.
Serum 25(OH)D level was significantly correlated with both skeletal muscle mass and lower limb muscle strength.
肌肉量和肌肉力量下降是跌倒的重要风险因素之一。近年来，维生素D在肌肉力量和身体活动中的作用日益受到关注。本研究旨在探讨中年健康成年人维生素D状态与肌肉量和肌肉力量之间的关系。
研究对象为40名年龄在42.0±10.6岁的健康志愿者。通过食物频率问卷对血清维生素D代谢产物（包括25-羟基维生素D[25(OH)D]和24,25-二羟基维生素D[24,25(OH)D]）浓度、下肢肌肉力量和饮食摄入量进行评估。采用双能X线吸收法（DXA）测量身体成分，并计算四肢骨骼肌质量指数（ASMI），即骨骼肌质量/身高的平方。
70%的受试者存在维生素D不足/缺乏（血清总25(OH)D<20 ng/mL），女性受试者的血清总25(OH)D水平显著低于男性。维生素D不足/缺乏组的体脂显著更高，SMI和肌肉力量更低，这可能反映了女性受试者的比例更高。血清维生素D代谢产物水平与整体和特定部位的ASMI以及下肢肌肉力量显著相关，但血清24,25(OH)D浓度与下肢肌肉力量之间无相关性。此外，血清25(OH)D水平是ASMI和下肢肌肉力量的显著正向预测因子，而血清24,25(OH)D水平不是它们的显著预测因子。
血清25(OH)D水平与骨骼肌质量和下肢肌肉力量均显著相关。
