Fouda Abdel-Motaal, Youssef Amany Ragab
Clinical Pharmacology & Therapeutics, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Osteoporos Sarcopenia. 2017 Sep;3(3):132-137. doi: 10.1016/j.afos.2017.07.002. Epub 2017 Jul 29.
The effect of sticks on prevention of tooth decay is well established, but the effect of stick extract (SPE) on the prevention/treatment of osteoporosis has not been studied. The purpose of this study is to provide baseline information of the effectiveness of SPE on ovariectomized (OVX) rat model of osteoporosis.
SPE was administered at 50, 150, and 300 mg/d orally to OVX rats for 16 weeks. Serum osteocalcin, alkaline phosphatase, calcium, and phosphorus, and urinary deoxypyridinoline, calcium, and phosphorus were measured. Bone mineral density (BMD), 3-point bending test, and histomorphometric characteristics of the femoral bone were also examined.
SPE at doses of 150 and 300 mg/d, but not 50 mg/d, significantly prevented bone loss in OVX rats as proved by decreased biochemical markers of bone resorption and increased BMD and biomechanical indices of the femoral bone.
This study confirms a dose-dependent protective action of SPE on rat OVX model of osteoporosis. This effect needs further investigation at the molecular and clinical levels to provide a natural and cost-effective alternative for the management of postmenopausal osteoporosis.
牙棒预防龋齿的效果已得到充分证实，但牙棒提取物（SPE）对骨质疏松症预防/治疗的效果尚未得到研究。本研究的目的是提供SPE对去卵巢（OVX）大鼠骨质疏松模型有效性的基线信息。
以50、150和300mg/d的剂量对OVX大鼠口服给予SPE，持续16周。测量血清骨钙素、碱性磷酸酶、钙和磷，以及尿脱氧吡啶啉、钙和磷。还检查了股骨的骨密度（BMD）、三点弯曲试验和组织形态计量学特征。
150和300mg/d剂量的SPE可显著预防OVX大鼠的骨质流失，这通过骨吸收生化标志物的降低以及股骨BMD和生物力学指标的增加得到证实，而50mg/d剂量的SPE则无此效果。
本研究证实了SPE对大鼠OVX骨质疏松模型具有剂量依赖性保护作用。这种作用需要在分子和临床水平上进一步研究，以为绝经后骨质疏松症的管理提供一种天然且经济有效的替代方法。
